Investigation of biphasic calcium phosphate (BCp)/polyvinylpyrrolidone (PVp) /graphene oxide (GO) composite for biomedical implants

Prem Ananth，K.1; Guo，Binbin1; Zhang，Chen1; Wang，Wei1,2; Zhou，Peng3; Bai，Jiaming1

2020-10-15

10.1016/j.ceramint.2020.06.224

CERAMICS INTERNATIONAL   影响因子和分区

0272-8842

1873-3956

The potential advantages of using 2D graphene oxide (GO)-based composites stimulating cellular differentiation as well as improve the compressive strength of the scaffolds. The present study investigated the biphasic calcium phosphate (BCp)/polyvinylpyrrolidone (PVp)/Graphene oxide (GO) composite with different GO (w/w) content of 1 wt%, 3 wt%, and 5 wt%. When increasing GO content, the compressive strength of scaffolds increased by 366 ± 37, 387 ± 28, and 558 ± 14 for 1 wt%, 3 wt%, and 5 wt% respectively.The TEM images showed the presence of a homogeneous distribution of BCp nanoparticles onto the graphene oxide surface; also Raman and XRD results confirm the formation of composite scaffolds. Furthermore, in vitro cytocompatibility of the BCp-PVp/GO 5 wt% composites were evaluated by cell adhesion and live/dead analysis using MG-63 cells. The obtained results showed that no adverse effect was witnessed, which evidences the superior bio compatibility nature of the composite scaffold. These results suggested that the BCp-PVp/GO composites could be a promising material for tissue engineering application.

Biomedical implant Biphasic calcium phosphate Composite Graphene oxide Mechanical strength

SCI ; EI

英语

第一

Shenzhen Key Laboratory for Additive Manufacturing of High-Performance Materials[ZDSYS201703031748354]

Materials Science

Materials Science, Ceramics

WOS:000564524900006

ELSEVIER SCI LTD

20202808923726

Calcium phosphate ; Compressive strength ; Cell adhesion ; Scaffolds (biology)

Biomedical Engineering:461.1 ; Biology:461.9 ; Minerals:482.2 ; Nanotechnology:761 ; Chemical Products Generally:804 ; Inorganic Compounds:804.2

MATERIALS SCIENCE

2-s2.0-85087738205

Scopus

1.Shenzhen Key Laboratory for Additive Manufacturing of High-Performance Materials,Department of Mechanical and Energy Engineering,Southern University of Science and Technology,Shenzhen,518055,China
2.Department of Materials Science and Engineering,City University of Hong Kong,Kowloon,Hong Kong
3.Institute of Intelligent Manufacturing Technology,Shenzhen Polytechnic,Shenzhen,China

Prem Ananth，K.,Guo，Binbin,Zhang，Chen,et al. Investigation of biphasic calcium phosphate (BCp)/polyvinylpyrrolidone (PVp) /graphene oxide (GO) composite for biomedical implants[J]. CERAMICS INTERNATIONAL,2020,46(15):24413-24423.

Prem Ananth，K.,Guo，Binbin,Zhang，Chen,Wang，Wei,Zhou，Peng,&Bai，Jiaming.(2020).Investigation of biphasic calcium phosphate (BCp)/polyvinylpyrrolidone (PVp) /graphene oxide (GO) composite for biomedical implants.CERAMICS INTERNATIONAL,46(15),24413-24423.

Prem Ananth，K.,et al."Investigation of biphasic calcium phosphate (BCp)/polyvinylpyrrolidone (PVp) /graphene oxide (GO) composite for biomedical implants".CERAMICS INTERNATIONAL 46.15(2020):24413-24423.