Recent progress on the role of miR-140 in cartilage matrix remodelling and its implications for osteoarthritis treatment

Duan，Li1; Liang，Yujie1,2; Xu，Xiao1; Xiao，Yin3; Wang，Daping1,4

2020-08-18

10.1186/s13075-020-02290-0

Arthritis Research and Therapy   影响因子和分区

1478-6354

1478-6362

Cartilage matrix remodelling homeostasis is a crucial factor in maintaining cartilage integrity. Loss of cartilage integrity is a typical characteristic of osteoarthritis (OA). Strategies aimed at maintaining cartilage integrity have attracted considerable attention in the OA research field. Recently, a series of studies have suggested dual functions of microRNA-140 (miR-140) in cartilage matrix remodelling. Here, we discuss the significance of miR-140 in promoting cartilage formation and inhibiting degeneration. Additionally, we focused on the role of miR-140 in the chondrogenesis of mesenchymal stem cells (MSCs). Of note, we carefully reviewed recent advances in MSC exosomes for miRNA delivery in OA treatment.

Anabolism Cartilage matrix Catabolism miR-140 Osteoarthritis

SCI

英语

其他

National Natural Science Foundation of China[81772394][81972116] ; Key Program of Natural Science Foundation of Guangdong Province[2018B0303110003] ; Shenzhen Science and Technology Projects[KQTD20170331100838136]

Rheumatology

Rheumatology

WOS:000564282600001

BMC

CLINICAL MEDICINE

2-s2.0-85089631976

Scopus

1.Department of Orthopedics,Shenzhen Intelligent Orthopaedics and Biomedical Innovation Platform,Guangdong Artificial Intelligence Biomedical Innovation Platform,Shenzhen Second People's Hospital,First Affiliated Hospital of Shenzhen University Health Science Center,Shenzhen,518035,China
2.Department of Child and Adolescent Psychiatry,Shenzhen Kangning Hospital,Shenzhen Mental Health Center,Shenzhen,518003,China
3.Institute of Health and Biomedical Innovation,Faculty of Science and Engineering,Queensland University of Technology,Kelvin Grove Campus,Brisbane,4059,Australia
4.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China

Duan，Li,Liang，Yujie,Xu，Xiao,et al. Recent progress on the role of miR-140 in cartilage matrix remodelling and its implications for osteoarthritis treatment[J]. Arthritis Research and Therapy,2020,22(1).

Duan，Li,Liang，Yujie,Xu，Xiao,Xiao，Yin,&Wang，Daping.(2020).Recent progress on the role of miR-140 in cartilage matrix remodelling and its implications for osteoarthritis treatment.Arthritis Research and Therapy,22(1).

Duan，Li,et al."Recent progress on the role of miR-140 in cartilage matrix remodelling and its implications for osteoarthritis treatment".Arthritis Research and Therapy 22.1(2020).