南方科技大学知识苑(SUSTech KC): The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy

题名	The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy
作者	Yuan，Jimin 1,2; Dong，Xiaoduo 3; Yap，Jiajun 4; Hu，Jiancheng 4,5
发表日期	2020-08-17
DOI	10.1186/s13045-020-00949-4
发表期刊	Journal of Hematology & Oncology 影响因子和分区
ISSN	1756-8722
EISSN	1756-8722
卷号	13 期号:1
摘要	Cancer is characterized as a complex disease caused by coordinated alterations of multiple signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined pathways in cancer biology, and its hyperactivation is responsible for over 40% human cancer cases. To drive carcinogenesis, this signaling promotes cellular overgrowth by turning on proliferative genes, and simultaneously enables cells to overcome metabolic stress by inhibiting AMPK signaling, a key singular node of cellular metabolism. Recent studies have shown that AMPK signaling can also reversibly regulate hyperactive MAPK signaling in cancer cells by phosphorylating its key components, RAF/KSR family kinases, which affects not only carcinogenesis but also the outcomes of targeted cancer therapies against the MAPK signaling. In this review, we will summarize the current proceedings of how MAPK-AMPK signalings interplay with each other in cancer biology, as well as its implications in clinic cancer treatment with MAPK inhibition and AMPK modulators, and discuss the exploitation of combinatory therapies targeting both MAPK and AMPK as a novel therapeutic intervention.
关键词	AMPK activators AMPK inhibitors AMPK signaling Autophagy Cellular metabolism Interplay RAF/MEK/ERK inhibitors Ras/RAF/MEK/ERK signaling Targeted therapy Tumorigenesis
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
重要成果	ESI高被引
学校署名	第一
资助项目	Asia Fund for Cancer Research[AFCR-2017/2019JH] ; SingHealth Foundation[AM/TP011/2018] ; NMRC[OFIRG18nov-0078]
WOS研究方向	Oncology ; Hematology
WOS类目	Oncology ; Hematology
WOS记录号	WOS:000563183100001
出版者	BMC
Scopus记录号	2-s2.0-85089643433
来源库	Scopus
引用统计	被引频次[WOS]：271
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/153301
专题	南方科技大学第一附属医院
作者单位	1.Department of Urology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, China 2.Geriatric Department, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, China 3.Shenzhen People's Hospital,Shenzhen,1017 Dongmen North Road,518020,China 4.Cancer and Stem Cell Program,Duke-NUS Medical School,8 College Road,169857,Singapore 5.Division of Cellular and Molecular Research,National Cancer Centre Singapore ,11 Hospital Drive,169610,Singapore
第一作者单位	南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Yuan，Jimin,Dong，Xiaoduo,Yap，Jiajun,et al. The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy[J]. Journal of Hematology & Oncology,2020,13(1).
APA	Yuan，Jimin,Dong，Xiaoduo,Yap，Jiajun,&Hu，Jiancheng.(2020).The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy.Journal of Hematology & Oncology,13(1).
MLA	Yuan，Jimin,et al."The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy".Journal of Hematology & Oncology 13.1(2020).