南方科技大学知识苑(SUSTech KC): 2D AuPd alloy nanosheets: One-step synthesis as imaging-guided photonic nano-antibiotics

题名	2D AuPd alloy nanosheets: One-step synthesis as imaging-guided photonic nano-antibiotics
作者	He，Songliang 1; Zhu，Guoshuai 1; Sun，Zhencheng 1; Wang，Jidong 2,3; Hui，Ping 1; Zhao，Penghe 1; Chen，Wenwen 1,3; Jiang，Xingyu4
通讯作者	Chen，Wenwen
发表日期	2020-08-01
DOI	10.1039/d0na00342e
发表期刊	Nanoscale Advances 影响因子和分区
ISSN	2516-0230
EISSN	2516-0230
卷号	2 期号:8页码:3550-3560
摘要	The complicated synthesis and undesirable biocompatibility of nanomaterials hinder the synergistic photothermal/photodynamic therapy for bacterial infections. Herein, we develop a one-step preparation method of 2D AuPd alloy nanosheets as imaging-guided photonic nano-antibiotics. 2D AuPd alloy nanosheets with an extremely small thickness (∼1.5 nm) exhibit prominent photothermal effects (η = 76.6%), excellent ROS generation, strong photoacoustic signals and desirable biocompatibility. AuPd nanosheets can eliminate 100% of representative Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli) when irradiated using an 808 nm laser at 1 W cm-2 for 5 minutes. After being modified with a bacterial targeting peptide, under the guidance of photoacoustic imaging, AuPd nanosheets achieve promising synergistic photothermal/photodynamic therapeutic efficacy in treating Staphylococcus aureus infected mice. This work expands the biomedical application of 2D noble metal nanomaterials to the field of photonic nano-antibiotics.
相关链接	[Scopus记录]
收录类别	ESCI ; EI
语种	英语
学校署名	其他
资助项目	National Natural Science Foundation of China[81701789][81702102] ; Shenzhen Basic Research Project[JCYJ20170818144006925][JCYJ20170307153359306] ; Medical Research Foundation in Guangdong Province[A2018154]
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000559380900043
出版者	ROYAL SOC CHEMISTRY
EI入藏号	20203609122344
EI主题词	Mammals ; Nanostructured materials ; Palladium alloys ; Binary alloys ; Medical applications ; Biocompatibility ; Escherichia coli ; Gold alloys ; Nanosheets ; Precious metals
EI分类号	Medicine and Pharmacology:461.6 ; Immunology:461.9.1 ; Precious Metals:547.1 ; Nanotechnology:761 ; Solid State Physics:933 ; Crystalline Solids:933.1
Scopus记录号	2-s2.0-85089969372
来源库	Scopus
引用统计	被引频次[WOS]：15
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/153591
专题	工学院_生物医学工程系
作者单位	1.Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging,School of Biomedical Engineering,Shenzhen University Health Science Center,Shenzhen,518055,China 2.Central Laboratory,Huazhong University of Science and Technology,Union Shenzhen Hospital,Nanshan Hospital,Shenzhen Nanshan People's Hospital,6th Affiliated Hospital of Shenzhen University Health Science Center,Shenzhen,518052,China 3.John A. Paulson School of Engineering and Applied Sciences,Harvard University,Cambridge,02138,United States 4.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
推荐引用方式 GB/T 7714	He，Songliang,Zhu，Guoshuai,Sun，Zhencheng,et al. 2D AuPd alloy nanosheets: One-step synthesis as imaging-guided photonic nano-antibiotics[J]. Nanoscale Advances,2020,2(8):3550-3560.
APA	He，Songliang.,Zhu，Guoshuai.,Sun，Zhencheng.,Wang，Jidong.,Hui，Ping.,...&Jiang，Xingyu.(2020).2D AuPd alloy nanosheets: One-step synthesis as imaging-guided photonic nano-antibiotics.Nanoscale Advances,2(8),3550-3560.
MLA	He，Songliang,et al."2D AuPd alloy nanosheets: One-step synthesis as imaging-guided photonic nano-antibiotics".Nanoscale Advances 2.8(2020):3550-3560.