Identification and validation of hypoxic markers of glioblastoma multiforme in methylation, somatic CNV characteristics based on large-scale samples

Wang，Jin1; Xu，Shihai1; Lv，Wen1; Shan，Aijun1; Shi，Fei1; Xu，Jianzhong1; Mei，Shanshan1; Yang，Ying2

2020

10.1002/jbt.22585

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY   影响因子和分区

1095-6670

1099-0461

This study conducted a systematic analysis of hypoxia-related genes (HRGs) to explore new markers for predicting the prognosis of glioblastoma (GBM). The gene expression profile and corresponding methylation, copy number variation (CNV), and genomic mutation data were downloaded from The Cancer Genome Atlas database. Two GEO cohorts were used to identify HRGs. The CGGA and GSE13041 were performed as validation cohorts. The hierarchical clustering algorithm was used to cluster molecular subtypes. Univariate cox analysis was used to assess prognosis. Spearman's method was conducted to evaluate the correlation among HRGs, methylation, and CNV. Finally, 158 HRGs were identified. Two molecular subtypes with significant prognosis were classified based on the expression of HRGs. The HRGs were mainly negatively correlated with methylation but were positively correlated with the somatic CNV. Based on the distinct prognoses revealed in univariate cox analysis, a 5-HRGs prognostic risk model was constructed and validated for predicting the survival of GBM patients.

CNV GBM hypoxia methylation molecular subtype prognostic risk model

SCI

英语

第一

PHARMACOLOGY & TOXICOLOGY

2-s2.0-85088378658

Scopus

1.Department of Emergency,Shenzhen People's Hospital (The Second Clinical Medical College,Jinan University; The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,China
2.Department of Pediatrics,Futian Women and Children Health Institute,Shenzhen,China

Wang，Jin,Xu，Shihai,Lv，Wen,et al. Identification and validation of hypoxic markers of glioblastoma multiforme in methylation, somatic CNV characteristics based on large-scale samples[J]. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY,2020.

Wang，Jin.,Xu，Shihai.,Lv，Wen.,Shan，Aijun.,Shi，Fei.,...&Yang，Ying.(2020).Identification and validation of hypoxic markers of glioblastoma multiforme in methylation, somatic CNV characteristics based on large-scale samples.JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY.

Wang，Jin,et al."Identification and validation of hypoxic markers of glioblastoma multiforme in methylation, somatic CNV characteristics based on large-scale samples".JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2020).