Pim1 kinase provides protection against high glucose-induced stress and apoptosis in cultured dorsal root ganglion neurons

Liu，Yuantong1,2; Shang，Yue1; Yan，Zihan1; Li，Hao3; Wang，Zhen1; Li，Zhenzhong1; Liu，Zhen1

2020

10.1016/j.neures.2020.06.004

NEUROSCIENCE RESEARCH   影响因子和分区

0168-0102

1872-8111

The pathogenesis of diabetic peripheral neuropathy (DPN) is complex and not well understood. Recently, oxidative stress and endoplasmic reticulum (ER) stress induced by hyperglycemia have been demonstrated to play a critical role in neuronal apoptosis, which then contributing to DPN. However, the specific molecular mechanism that underlies the hyperglycemia-induced neuronal stresses and apoptosis remains largely unknown. In this study, we demonstrated for the first time that Pim1 kinase is a positive modulator of dorsal root ganglion (DRG) neuron survival in vitro. Hyperglycemia causes compensatory upregulation of Pim1 kinase in the DRG neurons, which provides protection against high glucose-induced oxidative stress and ER stress. Pharmacological inhibition of Pim1 not only sensitizes the stress response to high glucose in the DRG neurons, but also accelerates the apoptosis of DRG neurons in vitro. Therefore, our work provides experimental evidence for the prevention of high glucose-induced neuronal stress and apoptosis by targeting Pim1 kinase.

Apoptosis Diabetic peripheral neuropathy Dorsal root ganglion Endoplasmic reticulum stress Oxidative stress Pim1 kinase

SCI

英语

其他

Shandong Provincial KeyResearch and Development Project[2019GSF107062]

Neurosciences & Neurology

Neurosciences

WOS:000671690800003

ELSEVIER IRELAND LTD

NEUROSCIENCE & BEHAVIOR

2-s2.0-85087364960

Scopus

1.Department of Anatomy,Shandong University School of Basic Medical Sciences,Jinan,250012,China
2.Department of Spine Surgery,Shenzhen People's Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,518020,China
3.Department of Orthopaedics,Shandong University Qilu Hospital,Jinan,250012,China

Liu，Yuantong,Shang，Yue,Yan，Zihan,et al. Pim1 kinase provides protection against high glucose-induced stress and apoptosis in cultured dorsal root ganglion neurons[J]. NEUROSCIENCE RESEARCH,2020,169.

Liu，Yuantong.,Shang，Yue.,Yan，Zihan.,Li，Hao.,Wang，Zhen.,...&Liu，Zhen.(2020).Pim1 kinase provides protection against high glucose-induced stress and apoptosis in cultured dorsal root ganglion neurons.NEUROSCIENCE RESEARCH,169.

Liu，Yuantong,et al."Pim1 kinase provides protection against high glucose-induced stress and apoptosis in cultured dorsal root ganglion neurons".NEUROSCIENCE RESEARCH 169(2020).