Colorectal Tumor Microenvironment-Activated Bio-Decomposable and Metabolizable Cu2O@CaCO(3)Nanocomposites for Synergistic Oncotherapy

Chang, Mengyu1,2; Hou, Zhiyao1,3,4; Jin, Dayong5,6; Zhou, Jiajia5; Wang, Man; Wang, Meifang1,2,7; Shu, Mengmeng1; Ding, Binbin1,2; Li, Chunxia7; Lin, Jun1,2

2020-09-18

10.1002/adma.202004647

ADVANCED MATERIALS   影响因子和分区

0935-9648

1521-4095

Rational design of tumor microenvironment (TME)-activated nanocomposites provides an innovative strategy to construct responsive oncotherapy. In colorectal cancer (CRC), the specific physiological features are the overexpressed endogenous H2S and slightly acidic microenvironment. Here, a core-shell Cu2O@CaCO(3)nanostructure for CRC "turn-on" therapy is reported. With CaCO(3)responsive to pH decomposition and Cu2O responsive to H2S sulfuration, Cu2O@CaCO(3)can be triggered "on" into the therapeutic mode by the colorectal TME. When the CaCO(3)shell decomposes and releases calcium in acidic colorectal TME, the loss of protection from the CaCO(3)shell exposes the Cu2O core to be sulfuretted by H2S to form metabolizable Cu(31)S(16)nanocrystals that gain remarkably strong near-infrared absorption. After modifying hyaluronic acid, Cu2O@CaCO(3)can achieve synergistic CRC-targeted and TME-triggered photothermal/photodynamic/chemodynamic/calcium-overload-mediated therapy. Moreover, it is found that the generation of hyperthermia and oxidative stress from Cu2O@CaCO(3)nanocomposites can efficiently reprogram the macrophages from the M2 phenotype to the M1 phenotype and initiate a vaccine-like immune effect after primary tumor removal, which further induces an immune-favorable TME and intense immune responses for anti-CD47 antibody to simultaneously inhibit CRC distant metastasis and recurrence by immunotherapy.

bio-decomposition colorectal tumor microenvironment Cu2O@CaCO3 metabolism synergistic oncotherapy

SCI ; EI

英语

NI期刊 ; NI论文

通讯

Chinese Government[2017YFE0132300] ; Australian Government[2017YFE0132300] ; National Natural Science Foundation of China[NSFC 51929201][51672268][51720105015][51972138][51872263][51828202] ; Science and Technology Development Planning Project of Jilin Province[20190201232JC] ; CAS-Croucher Funding Scheme for Joint Laboratories[CAS18204] ; Guangdong Natural Science Foundation[2019A1515012214]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000570217200001

WILEY-V C H VERLAG GMBH

20203809204105

Infrared devices ; Tumors ; Diseases ; Calcite ; Hyaluronic acid ; Hyperthermia therapy ; Light absorption ; Nanocomposites

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Minerals:482.2 ; Light/Optics:741.1 ; Nanotechnology:761 ; Chemical Products Generally:804 ; Organic Compounds:804.1 ; Inorganic Compounds:804.2 ; Solid State Physics:933

MATERIALS SCIENCE

Web of Science

1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China
2.Univ Sci & Technol China, Sch Appl Chem & Engn, Hefei 230026, Peoples R China
3.Guangzhou Med Univ, Sch Basic Med Sci, Guangzhou Municipal & Guangdong Prov Key Lab Prot, Guangzhou 511436, Guangdong, Peoples R China
4.Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Dept Abdominal Surg, Guangzhou 510095, Peoples R China
5.Univ Technol Sydney, Fac Sci, Inst Biomed Mat & Devices, 15 Broadway, Ultimo, NSW 2007, Australia
6.Southern Univ Sci & Technol, Dept Biomed Engn, UTS SUStech Joint Res Ctr Biomed Mat & Devices, Shenzhen 518055, Peoples R China
7.Shandong Univ, Inst Mol Sci & Engn, Qingdao 266237, Peoples R China

Chang, Mengyu,Hou, Zhiyao,Jin, Dayong,et al. Colorectal Tumor Microenvironment-Activated Bio-Decomposable and Metabolizable Cu2O@CaCO(3)Nanocomposites for Synergistic Oncotherapy[J]. ADVANCED MATERIALS,2020,32(43).

Chang, Mengyu.,Hou, Zhiyao.,Jin, Dayong.,Zhou, Jiajia.,Wang, Man.,...&Lin, Jun.(2020).Colorectal Tumor Microenvironment-Activated Bio-Decomposable and Metabolizable Cu2O@CaCO(3)Nanocomposites for Synergistic Oncotherapy.ADVANCED MATERIALS,32(43).

Chang, Mengyu,et al."Colorectal Tumor Microenvironment-Activated Bio-Decomposable and Metabolizable Cu2O@CaCO(3)Nanocomposites for Synergistic Oncotherapy".ADVANCED MATERIALS 32.43(2020).