Tissue-engineered parathyroid gland and its regulatory secretion of parathyroid hormone

Li, Duo1,2; Guo, Baochun3,4,5; Liang, Qingfei1,2; Liu, Yunhui2,6; Zhang, Lu6; Hu, Nan3,4,5; Zhang, Xinzhou3,4,5; Yang, Fan2,6; Ruan, Changshun1,2

2020-08-13

10.1002/term.3080

Journal of Tissue Engineering and Regenerative Medicine   影响因子和分区

1932-6254

1932-7005

Parathyroid glands (PTGs) are important endocrine organs being mainly responsible for the secretion of parathyroid hormone (PTH) to regulate the balance of calcium (Ca) /phosphorus (P) ions in the body. Once PTGs get injured or removed, their resulting defect or loss of PTH secretion should disturb the level of Ca/P in blood, thus damaging other related organs (bone, kidney, etc.) and even causing death. Recently, tissue-engineered PTGs (TE-PTGs) have attracted lots of attention as a potential treatment for the related diseases of PTGs caused by hypoparathyroidism and hyperparathyroidism, including tetany, muscle cramp, nephrolithiasis, nephrocalcinosis, and osteoporosis. Although great progress has been made in the establishment of TE-PTGs with an effective strategy to integrate the key factors of cells and biomaterials, its regulatory secretion of PTH to mimic its natural rhythms in the body remains a huge challenge. This review comprehensively describes an overview of PTGs from physiology and pathology to cytobiology and tissue engineering. The state of the arts in TE-PTGs and the feasible strategies to regulate PTH secretion behaviors are highlighted to provide an important foundation for further investigation.

biomaterials parathyroid glands parathyroid hormone regulation seeding cells tissue engineering

SCI ; EI

英语

通讯

National Key Research and Development Program[2018YFA0703100] ; National Natural Science Foundation of China[31771041] ; Youth Innovation Promotion Association of CAS[2019350] ; Key Laboratory of Shenzhen Renal Diseases[ZDSYS201504301616234] ; Shenzhen Fundamental Research Foundation[JCYJ20180507182301299][JCYJ20180507182237428] ; Shenzhen Healthcare Research Project[SZSJ2017038]

Cell Biology ; Biotechnology & Applied Microbiology ; Engineering

Cell & Tissue Engineering ; Biotechnology & Applied Microbiology ; Cell Biology ; Engineering, Biomedical

WOS:000559059600001

WILEY

Web of Science

1.Chinese Acad Sci, Res Ctr Human Tissue & Organs Degenerat, Inst Biomed & Biotechnol, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Nephrol, Shenzhen, Peoples R China
4.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China
5.Key Lab Shenzhen Renal Dis, Shenzhen, Peoples R China
6.Chinese Acad Sci, Brain Cognit & Brain Dis Inst, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China

Li, Duo,Guo, Baochun,Liang, Qingfei,et al. Tissue-engineered parathyroid gland and its regulatory secretion of parathyroid hormone[J]. Journal of Tissue Engineering and Regenerative Medicine,2020.

Li, Duo.,Guo, Baochun.,Liang, Qingfei.,Liu, Yunhui.,Zhang, Lu.,...&Ruan, Changshun.(2020).Tissue-engineered parathyroid gland and its regulatory secretion of parathyroid hormone.Journal of Tissue Engineering and Regenerative Medicine.

Li, Duo,et al."Tissue-engineered parathyroid gland and its regulatory secretion of parathyroid hormone".Journal of Tissue Engineering and Regenerative Medicine (2020).