Successful management of seven cases of critical COVID-19 with early noninvasive-invasive sequential ventilation algorithm and bundle pharmacotherapy

Peng, Mian1; Liu, Xueyan2; Li, Jinxiu3; Ren, Di4; Liu, Yongfeng5; Meng, Xi3; Lyu, Yansi6; Chen, Ronglin5; Yu, Baojun7; Zhong, Weixiong1

2020-08-06

10.1007/s11684-020-0796-3

Frontiers of Medicine   影响因子和分区

2095-0217

2095-0225

We report the clinical and laboratory findings and successful management of seven patients with critical coronavirus disease 2019 (COVID-19) requiring mechanical ventilation (MV). The patients were diagnosed based on epidemiological history, clinical manifestations, and nucleic acid testing. Upon diagnosis with COVID-19 of critical severity, the patients were admitted to the intensive care unit, where they received early noninvasive-invasive sequential ventilation, early prone positioning, and bundle pharmacotherapy regimen, which consists of antiviral, anti-inflammation, immune-enhancing, and complication-prophylaxis medicines. The patients presented fever (n= 7, 100%), dry cough (n= 3, 42.9%), weakness (n= 2, 28.6%), chest tightness (n= 1, 14.3%), and/or muscle pain (n= 1, 14.3%). All patients had normal or lower than normal white blood cell count/lymphocyte count, and chest computed tomography scans showed bilateral patchy shadows or ground glass opacity in the lungs. Nucleic acid testing confirmed COVID-19 in all seven patients. The median MV duration and intensive care unit stay were 9.9 days (interquartile range, 6.5-14.6 days; range, 5-17 days) and 12.9 days (interquartile range, 9.7-17.6 days; range, 7-19 days), respectively. All seven patients were extubated, weaned off MV, transferred to the common ward, and discharged as of the writing of this report. Thus, we concluded that good outcomes for patients with critical COVID-19 can be achieved with early noninvasive-invasive sequential ventilation and bundle pharmacotherapy.

COVID-19 noninvasive-invasive sequential ventilation bundle pharmacotherapy

SCI

英语

通讯

Oncology ; Research & Experimental Medicine

Oncology ; Medicine, Research & Experimental

WOS:000556620600001

SPRINGER

Web of Science

1.Shenzhen Univ, Dept Intens Care Unit, Affiliated Hosp 3, Shenzhen 518001, Peoples R China
2.Jinan Univ, Affiliated Hosp 2, Southern Univ Sci & Technol, Affiliated Hosp 1,Dept Intens Care Unit,Shenzhen, Shenzhen 518020, Peoples R China
3.Third Peoples Hosp Shenzhen, Dept Intens Care Unit, Shenzhen 518112, Peoples R China
4.Second Peoples Hosp Shenzhen, Dept Intens Care Unit, Shenzhen 518035, Peoples R China
5.Shenzhen Longgang Cent Hosp, Dept Intens Care Unit, Shenzhen 518116, Peoples R China
6.Shenzhen Univ Gen Hosp, Dept Dermatol, Shenzhen 518055, Peoples R China
7.Shenzhen Baoan Dist Peoples Hosp, Dept Intens Care Unit, Shenzhen 518101, Peoples R China

Peng, Mian,Liu, Xueyan,Li, Jinxiu,et al. Successful management of seven cases of critical COVID-19 with early noninvasive-invasive sequential ventilation algorithm and bundle pharmacotherapy[J]. Frontiers of Medicine,2020.

Peng, Mian.,Liu, Xueyan.,Li, Jinxiu.,Ren, Di.,Liu, Yongfeng.,...&Zhong, Weixiong.(2020).Successful management of seven cases of critical COVID-19 with early noninvasive-invasive sequential ventilation algorithm and bundle pharmacotherapy.Frontiers of Medicine.

Peng, Mian,et al."Successful management of seven cases of critical COVID-19 with early noninvasive-invasive sequential ventilation algorithm and bundle pharmacotherapy".Frontiers of Medicine (2020).