Rethinking Nano-TiO(2)Safety: Overview of Toxic Effects in Humans and Aquatic Animals

Luo, Zhen1,2; Li, Zhuoqing1,2; Xie, Zhe1,2; Sokolova, Inna M.3,4; Song, Lan5; Peijnenburg, Willie J. G. M.6,7; Hu, Menghong1,2; Wang, Youji1,2

2020-08-06

10.1002/smll.202002019

Small   影响因子和分区

1613-6810

1613-6829

Titanium dioxide nanoparticles (nano-TiO2) are widely used in consumer products, raising environmental and health concerns. An overview of the toxic effects of nano-TiO(2)on human and environmental health is provided. A meta-analysis is conducted to analyze the toxicity of nano-TiO(2)to the liver, circulatory system, and DNA in humans. To assess the environmental impacts of nano-TiO2, aquatic environments that receive high nano-TiO(2)inputs are focused on, and the toxicity of nano-TiO(2)to aquatic organisms is discussed with regard to the present and predicted environmental concentrations. Genotoxicity, damage to membranes, inflammation and oxidative stress emerge as the main mechanisms of nano-TiO(2)toxicity. Furthermore, nano-TiO(2)can bind with free radicals and signal molecules, and interfere with the biochemical reactions on plasmalemma. At the higher organizational level, nano-TiO(2)toxicity is manifested as the negative effects on fitness-related organismal traits including feeding, reproduction and immunity in aquatic organisms. Bibliometric analysis reveals two major research hot spots including the molecular mechanisms of toxicity of nano-TiO(2)and the combined effects of nano-TiO(2)and other environmental factors such as light and pH. The possible measures to reduce the harmful effects of nano-TiO(2)on humans and non-target organisms has emerged as an underexplored topic requiring further investigation.

bibliometric analysis ecotoxicity health meta-analysis titanium dioxide nanoparticles toxicity

SCI ; EI

英语

其他

Natural Science Foundation of China[31872587] ; Shanghai Pujiang Talent Program[18PJ1404000] ; [17ZR1412900]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000555850900001

WILEY-V C H VERLAG GMBH

20203209018002

Consumer products ; Toxicity ; Nanoparticles ; Free radicals ; Environmental impact ; Health ; Cell membranes ; Cardiovascular system ; Cell proliferation ; Titanium dioxide

Environmental Impact and Protection:454.2 ; Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Health Care:461.7 ; Biology:461.9 ; Marine Science and Oceanography:471 ; Nanotechnology:761 ; Inorganic Compounds:804.2 ; Solid State Physics:933

Web of Science

1.Shanghai Ocean Univ, Int Res Ctr Marine Biosci, Minist Sci & Technol, Shanghai 201306, Peoples R China
2.Shanghai Ocean Univ, Key Lab Explorat & Utilizat Aquat Genet Resources, Minist Educ, Shanghai 201306, Peoples R China
3.Univ Rostock, Inst Biol Sci, Dept Marine Biol, D-18051 Rostock, Germany
4.Univ Rostock, Interdisciplinary Fac, Dept Maritime Syst, D-18051 Rostock, Germany
5.Southern Univ Sci & Technol, Sch Environm Sci & Engn, Shenzhen 518055, Peoples R China
6.Leiden Univ, Inst Environm Sci CML, POB 9518, NL-2300 RA Leiden, Netherlands
7.Natl Inst Publ Hlth & Environm RIVM, Ctr Safety Subst & Prod, POB 1, NL-3720 BA Bilthoven, Netherlands

Luo, Zhen,Li, Zhuoqing,Xie, Zhe,et al. Rethinking Nano-TiO(2)Safety: Overview of Toxic Effects in Humans and Aquatic Animals[J]. Small,2020,16(36).

Luo, Zhen.,Li, Zhuoqing.,Xie, Zhe.,Sokolova, Inna M..,Song, Lan.,...&Wang, Youji.(2020).Rethinking Nano-TiO(2)Safety: Overview of Toxic Effects in Humans and Aquatic Animals.Small,16(36).

Luo, Zhen,et al."Rethinking Nano-TiO(2)Safety: Overview of Toxic Effects in Humans and Aquatic Animals".Small 16.36(2020).