Machine-Driven Chemoenzymatic Synthesis of Glycopeptide

Zhang, Jiabin1; Liu, Ding1; Saikam, Varma1; Gadi, Madhusudhan R.1; Gibbons, Christopher1; Fu, Xuan1; Song, Heliang1; Yu, Jin4; Kondengaden, Shukkoor M.2; Wang, Peng G.1,2; Wen, Liuqing1,3

2020-08-31

10.1002/anie.202001124

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   影响因子和分区

1433-7851

1521-3773

Historically, researchers have put considerable effort into developing automation systems to prepare natural biopolymers such as peptides and oligonucleotides. The availability of such mature systems has significantly advanced the development of natural science. Over the past twenty years, breakthroughs in automated synthesis of oligosaccharides have also been achieved. A machine-driven platform for glycopeptide synthesis by a reconstructed peptide synthesizer is described. The designed platform is based on the use of an amine-functionalized silica resin to facilitate the chemical synthesis of peptides in organic solvent as well as the enzymatic synthesis of glycan epitopes in the aqueous phase in a single reaction vessel. Both syntheses were performed by a peptide synthesizer in a semiautomated manner.

automation chemoenzymatic synthesis machine-driven peptide synthesizer silica resin

SCI ; EI

英语

NI期刊 ; NI论文

通讯

National Institutes of Health[U01GM116263] ; Shanghai Institute of Materia Medica[2019000021]

Chemistry

Chemistry, Multidisciplinary

WOS:000564021000001

WILEY-V C H VERLAG GMBH

20203609123081

Oligonucleotides ; Peptides ; Automation ; Resins

Biology:461.9 ; Automatic Control Principles and Applications:731 ; Organic Polymers:815.1.1

CHEMISTRY

Web of Science

1.Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA
2.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
4.Imperial Coll London, Du Cane Rd, London W12 0NN, England

Zhang, Jiabin,Liu, Ding,Saikam, Varma,et al. Machine-Driven Chemoenzymatic Synthesis of Glycopeptide[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020,59:19825-19829.

Zhang, Jiabin.,Liu, Ding.,Saikam, Varma.,Gadi, Madhusudhan R..,Gibbons, Christopher.,...&Wen, Liuqing.(2020).Machine-Driven Chemoenzymatic Synthesis of Glycopeptide.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,59,19825-19829.

Zhang, Jiabin,et al."Machine-Driven Chemoenzymatic Synthesis of Glycopeptide".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 59(2020):19825-19829.