Centimeter-Deep NIR-II Fluorescence Imaging with Nontoxic AIE Probes in Nonhuman Primates

Sheng, Zonghai1; Li, Yaxi2; Hu, Dehong1; Min, Tianliang2; Gao, Duyang1; Ni, Jen-Shyang2; Zhang, Pengfei1; Wang, Yuenan3,4; Liu, Xin1; Li, Kai2; Zheng, Hairong1; Tang, Ben Zhong5

2020-09-26

10.34133/2020/4074593

Research   影响因子和分区

2639-5274

2639-5274

Fluorescence probes with aggregation-induced emission (AIE) characteristics are of great importance in biomedical imaging with superior spatial and temporal resolution. However, the lack of toxicity studies and deep tissue imaging in nonhuman primates hinders their clinical translation. Here, we report the blood chemistry and histological analysis in nonhuman primates treated with AIE probes over tenfold of an intravenous dose of clinically used indocyanine green (ICG) during a study period of 36 days to demonstrate AIE probes are nontoxic. Furthermore, through bright and nontoxic AIE probes and fluorescence imaging in the second window (NIR-II, 1,000-1,700 nm), we achieve an unprecedented 1.5-centimeter-deep vascular imaging in nonhuman primates, breaking the current limitation of millimeter-deep NIR-II fluorescence imaging. Our important findings, i.e., nontoxic features of AIE probes and centimeter-deep NIR-II vascular imaging in nonhuman primates, may facilitate successful translation of AIE probes in clinical trials.

ESCI ; EI

英语

通讯

National Key Research and Development Program of China (Scientific and Technological Innovation Cooperation of Mainland and Macao)[2017YFE0120000] ; Natural Science Foundation of China[91859117][81771906][81901812][81527901][31870991] ; CAS Key Laboratory of Health Informatics[2011DP173015] ; Guangdong Innovative and Entrepreneurial Research Team Program[2019ZT08Y191] ; Science and Technology Innovation Fund of Shenzhen[JCYJ20170818161918918][JCYJ20190812163614809] ; Shenzhen Key Laboratory of Ultrasound Imaging and Therapy[ZDSYS201802061806314] ; China Postdoctoral Science Foundation[2019M653129]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000572823100001

AMER ASSOC ADVANCEMENT SCIENCE

Web of Science

1.Chinese Acad Sci, Key Lab Magnet Resonance & Multimodal Imaging Gua, Inst Biomed & Hlth Engn Shenzhen,Inst Adv Technol, Shenzhen Key Lab Ultrasound Imaging & Therapy,CAS, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol SUSTech, Dept Biomed Engn, Shenzhen 518055, Peoples R China
3.Chinese Acad Med Sci & Peking Union Med Coll, Dept Radiat Oncol, Natl Canc Ctr Natl Clin Res Ctr Canc, Canc Hosp, Shenzhen 518055, Peoples R China
4.Chinese Acad Med Sci & Peking Union Med Coll, Shenzhen Hosp, Shenzhen 518055, Peoples R China
5.Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Clear Water Bay, Hong Kong, Peoples R China

Sheng, Zonghai,Li, Yaxi,Hu, Dehong,et al. Centimeter-Deep NIR-II Fluorescence Imaging with Nontoxic AIE Probes in Nonhuman Primates[J]. Research,2020,2020.

Sheng, Zonghai.,Li, Yaxi.,Hu, Dehong.,Min, Tianliang.,Gao, Duyang.,...&Tang, Ben Zhong.(2020).Centimeter-Deep NIR-II Fluorescence Imaging with Nontoxic AIE Probes in Nonhuman Primates.Research,2020.

Sheng, Zonghai,et al."Centimeter-Deep NIR-II Fluorescence Imaging with Nontoxic AIE Probes in Nonhuman Primates".Research 2020(2020).