Engineered Live Biotherapeutics: Progress and Challenges

Tan, Yang1; Shen, Juntao1; Si, Tong1,2; Ho, Chun Loong3; Li, Yinqing4; Dai, Lei1,2

2020-09-13

10.1002/biot.202000155

Biotechnology Journal   影响因子和分区

1860-6768

1860-7314

The human microbiome plays an important role in human health, from metabolism to immunity. In the last few decades, advances in synthetic biology have enabled scientists to design and engineer live microorganisms for therapeutic purposes. In this review, major strategies for manipulating the microbiome are outlined, which include three emerging areas with promising therapeutic applications: engineered commensal bacteria, synthetic microbial consortia, and targeted modulation by phages. Furthermore, the applications of engineered live biotherapeutics in treating a variety of human diseases, including pathogenic infections, metabolic disorders, inflammatory bowel disease, and colorectal cancer, are highlighted. Finally, an overview of the challenges and opportunities in the future development of engineered live biotherapeutics is provided.

engineered commensal bacteria human diseases live biotherapeutics phages synthetic microbial consortia

SCI ; EI

英语

其他

National Key R&D Program of China[2019YFA09006700][2019YFA0904400] ; National Natural Science Foundation of China[31971513] ; Shenzhen Institute of Synthetic Biology[DWKF20190001] ; SIAT Innovation Program for Excellent Young Researchers[Y8G023] ; China Postdoctoral Science Foundation[2019M663166]

Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology

Biochemical Research Methods ; Biotechnology & Applied Microbiology

WOS:000568728800001

WILEY-V C H VERLAG GMBH

20203809201706

Metabolism ; Diseases ; Bacteriophages

Web of Science

1.Chinese Acad Sci, Shenzhen Inst Adv Technol SIAT, Shenzhen Inst Synthet Biol, CAS Key Lab Quantitat Engn Biol, Shenzhen 518055, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Southern Univ Sci & Technol SUSTech, SUSTech Acad Adv Interdisciplinary Studies, Dept Biomed Engn, Shenzhen 518055, Peoples R China
4.Tsinghua Univ, IDG McGovern Inst Brain Res, Sch Pharmaceut Sci, Beijing 100084, Peoples R China

Tan, Yang,Shen, Juntao,Si, Tong,et al. Engineered Live Biotherapeutics: Progress and Challenges[J]. Biotechnology Journal,2020,15(10).

Tan, Yang,Shen, Juntao,Si, Tong,Ho, Chun Loong,Li, Yinqing,&Dai, Lei.(2020).Engineered Live Biotherapeutics: Progress and Challenges.Biotechnology Journal,15(10).

Tan, Yang,et al."Engineered Live Biotherapeutics: Progress and Challenges".Biotechnology Journal 15.10(2020).