Highly Stretchable Metal-Polymer Conductor Electrode Array for Electrophysiology

Dong, Ruihua1,2; Liu, Xiaoyan3; Cheng, Shiyu2; Tang, Lixue3; Chen, Mian2; Zhong, Leni2; Chen, Zhen2; Liu, Shaoqin1; Jiang, Xingyu1,2,3

2020-09-16

10.1002/adhm.202000641

Advanced Healthcare Materials   影响因子和分区

2192-2640

2192-2659

Narrowing the mechanical mismatch between biological tissues (typically soft) and neural interfaces (hard) is essential for maintaining signal quality for the electrical recording of neural activity. However, only a few materials can satisfy all requirements for such electronics, which need to be both biocompatible and sufficiently soft. Here, a highly stretchable electrode array (SEA) is introduced, based on the liquid metal-polymer conductor (MPC), achieving high mechanical flexibility and good cytocompatability for neural interfaces. By utilizing the MPC, the SEA exhibits high stretchability (approximate to 100%) and excellent cycling stability (>400 cycles). The cytocompatability of the SEA can allow for long-term culturing of primary neurons and enable signal recording of primary hippocampal neurons. In the future, the SEA could serve as a reliable and robust platform for diagnostics in neuronal tissues and greatly advance brain-machine interfaces.

flexible electronics liquid metal-polymer conductors neural interfaces stretchable electrode arrays

SCI ; EI

英语

通讯

National Natural Science Foundation of China[81730051][21761142006][21535001] ; Guangdong Province Introduction of Innovative RD Team[2019ZT08Y191] ; Shenzhen Science and Technology Program[KQTD20190929172743294] ; National Key R&D Program of China[2018YFA0902600][2017YFA0205901] ; Chinese Academy of Sciences[QYZDJ-SSW-SLH039] ; Shenzhen Bay Laboratory[SZBL2019062801004]

Engineering ; Science & Technology - Other Topics ; Materials Science

Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials

WOS:000569760000001

WILEY

20203809202234

Electrophysiology ; Liquid metals ; Electrodes ; Tissue ; Neurons ; Histology ; Biocompatibility

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Immunology:461.9.1 ; Metallurgy:531.1 ; Electronic Equipment, General Purpose and Industrial:715

Web of Science

1.Harbin Inst Technol, Sch Life Sci & Technol, 2 Yikuang Rd, Harbin 150001, Peoples R China
2.Southern Univ Sci & Technol, Dept Biomed Engn, 1088 Xueyuan Rd, Shenzhen 518055, Guangdong, Peoples R China
3.Univ Chinese Acad Sci, Natl Ctr NanoSci & Technol, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China

Dong, Ruihua,Liu, Xiaoyan,Cheng, Shiyu,et al. Highly Stretchable Metal-Polymer Conductor Electrode Array for Electrophysiology[J]. Advanced Healthcare Materials,2020,10(4).

Dong, Ruihua.,Liu, Xiaoyan.,Cheng, Shiyu.,Tang, Lixue.,Chen, Mian.,...&Jiang, Xingyu.(2020).Highly Stretchable Metal-Polymer Conductor Electrode Array for Electrophysiology.Advanced Healthcare Materials,10(4).

Dong, Ruihua,et al."Highly Stretchable Metal-Polymer Conductor Electrode Array for Electrophysiology".Advanced Healthcare Materials 10.4(2020).