Clinical and pathological characteristics of ANA/anti-dsDNA positive patients with antineutrophil cytoplasmic autoantibody-associated vasculitis

Zhao, Xiaohong1,2,3; Wen, Qiong1; Qiu, Yagui1; Huang, Fengxian1

2020-09-22

10.1007/s00296-020-04704-3

RHEUMATOLOGY INTERNATIONAL   影响因子和分区

0172-8172

1437-160X

Antineutrophil cytoplasmic autoantibodies (ANCA) associated vasculitis (AAV) consists of a group of systemic autoimmune diseases. The roles of serum anti-nuclear antibodies (ANA) and anti-double-stranded DNA (anti-dsDNA) antibodies in AAV patients remain unknown. This study investigated the prevalence of serum ANAs and anti-dsDNA antibodies in AAV patients and characterized the clinical and pathological features of these patients. A total of 218 AAV patients were enrolled. Clinical and pathological data of patients were analyzed retrospectively. Of the 218 AAV patients, 109 (50.0%) were positive for ANA, 45 (20.6%) were positive for anti-dsDNA, and 43 (19.7%) were positive for both. The AAV patients with ANA had severer kidney damage and more chronic renal histopathological changes compared to those who were negative for ANA. Specifically, patients positive for ANA had more hypertension, higher levels of urea nitrogen and serum creatinine, lower estimated glomerular filtration rate (eGFR), more end-stage renal disease (ESRD), severer proteinuria, glomerular sclerosis, tubular interstitial fibrosis and tubular atrophy, and were more likely to receive renal biopsies compared to ANA negative patients. The study found ANA and anti-dsDNA in AVV patients were not rare, ANA-positive AAV patients had severer kidney damage and more chronic renal histopathological changes compared to ANA-negative AAV patients. Renal biopsy is strongly recommended for differential diagnosis in such cases.

Antineutrophil cytoplasmic autoantibodies (ANCA) Associated vasculitis (AAV) Clinicopathological characteristics Anti-nuclear antibody (ANA) Anti-double stranded DNA antibodies (anti-dsDNA)

SCI

英语

其他

Natural Science Foundation of China[81870575][81570750] ; Key Research and Development Project of China[2016YFCO906100] ; Science and Technology Project of Guangdong Province[2017B020227006]

Rheumatology

Rheumatology

WOS:000572033800001

SPRINGER HEIDELBERG

CLINICAL MEDICINE

Web of Science

1.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Key Lab Nephrol,Natl Hlth Commiss, 58th Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China
2.Jinan Univ, Shenzhen Key Lab Nephrol Dis, Shenzhen Peoples Hosp, Dept Nephrol,Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China

Zhao, Xiaohong,Wen, Qiong,Qiu, Yagui,et al. Clinical and pathological characteristics of ANA/anti-dsDNA positive patients with antineutrophil cytoplasmic autoantibody-associated vasculitis[J]. RHEUMATOLOGY INTERNATIONAL,2020,41(2).

Zhao, Xiaohong,Wen, Qiong,Qiu, Yagui,&Huang, Fengxian.(2020).Clinical and pathological characteristics of ANA/anti-dsDNA positive patients with antineutrophil cytoplasmic autoantibody-associated vasculitis.RHEUMATOLOGY INTERNATIONAL,41(2).

Zhao, Xiaohong,et al."Clinical and pathological characteristics of ANA/anti-dsDNA positive patients with antineutrophil cytoplasmic autoantibody-associated vasculitis".RHEUMATOLOGY INTERNATIONAL 41.2(2020).