Effect of HIF-1 alpha siRNA-linked AuNRs on radiotherapy of nasopharyngeal carcinoma

Xui, Gang1; Zhang, Haosheng1; Li, Zhibin2; Wu, Shihai1; Quan, Rencui1; Mao, Kun1; Sheng, Yang1; Li, Xianming1

2020

10.14715/cmb/2020.60.5.31

CELLULAR AND MOLECULAR BIOLOGY   影响因子和分区

0145-5680

1165-158X

The radiation sensitivity of tumor cells is closely related to tumor cell hypoxia. Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is considered a key transcription factor which regulates the sensitivity of hypoxic tumor cells to radiotherapy. On the other hand, some studies have shown that gold nanomaterials improve radiation sensitivity. However, studies on the effect of gold nanomaterials carrying HIF-1 alpha siRNA on tumor radiotherapy, and the underlying mechanisms are limited. Thus, the present study was aimed at investigating the effect of gold nanocomposites (AuNRs) carrying HIF-1 alpha siRNA (AuNRs-HIF-1 alpha siRNA) on the radiation sensitivity of nasopharyngeal carcinoma (NPC) hypoxia cells. The effect of AuNRs-HIF-1 alpha siRNA on radiation sensitivity of hypoxic NPC cells was determined under X-ray irradiation. The results showed that Au-HIF-1 alpha siRNA improved the radio-sensitivity of NPC tumor. Thus, this study has demonstrated that gold nanomaterials can HIF-1 alpha siRNA effectively increased the radio-sensitivity of hypoxic tumor, thereby improving the effect of radiotherapy on NPC cells.

AuNRs HIF-1 alpha siRNA Radiotherapy Sensitivity NPC Hypoxias

SCI

英语

第一 ; 通讯

Basic Research Project of Science and Technology Plan of Shenzhen[JCYJ20170307100227392]

Biochemistry & Molecular Biology ; Cell Biology

Biochemistry & Molecular Biology ; Cell Biology

WOS:000558679700030

C M B ASSOC

MOLECULAR BIOLOGY & GENETICS

Web of Science

1.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp,Clin Med Coll 2,Dept Radiat, Shenzhen 518020, Guangdong, Peoples R China
2.Chinese Acad Sci, Shenzhen Inst Adv Technol, Mat & Interfaces Ctr, Shenzhen 518055, Peoples R China

Xui, Gang,Zhang, Haosheng,Li, Zhibin,et al. Effect of HIF-1 alpha siRNA-linked AuNRs on radiotherapy of nasopharyngeal carcinoma[J]. CELLULAR AND MOLECULAR BIOLOGY,2020,66(5):185-190.

Xui, Gang.,Zhang, Haosheng.,Li, Zhibin.,Wu, Shihai.,Quan, Rencui.,...&Li, Xianming.(2020).Effect of HIF-1 alpha siRNA-linked AuNRs on radiotherapy of nasopharyngeal carcinoma.CELLULAR AND MOLECULAR BIOLOGY,66(5),185-190.

Xui, Gang,et al."Effect of HIF-1 alpha siRNA-linked AuNRs on radiotherapy of nasopharyngeal carcinoma".CELLULAR AND MOLECULAR BIOLOGY 66.5(2020):185-190.