Biological Safe Gold Nanoparticle-Modified Dental Aligner Prevents the Porphyromonas gingivalis Biofilm Formation

Zhang, Mengqi5; Liu, Xiaomo5; Xie, Yangzhouyun4; Zhang, Qian1; Zhang, Wei2,3; Jiang, Xingyu4; Lin, Jiuxiang5

2020-08-04

10.1021/acsomega.0c01532

ACS Omega   影响因子和分区

2470-1343

Oral microbiology could directly influence overall health. Porphyromonas gingivalis (P. gingivalis) is a highly pathogenic bacterium that causes periodontitis and other related systematic diseases, including Alzheimer's disease. Orthodontic devices (e.g., invisalign aligner) is commonly used in populations with periodontitis who are also at a high risk of systematic diseases. In this study, newly explored antibacterial 4,6-diamino-2-pyrimidinethiol-modified gold nanoparticles (AuDAPT) were coated onto aligners. The coated aligners showed favorable antibacterial activity against P. gingivalis. In the presence of the coated aligner, the number of planktonic cells was decreased, and biofilm formation was prevented. This material also showed favorable biocompatibility in vivo and in vitro. This study reveals a new method for treating oral P. gingivalis by coating aligners with AuDAPT, which has typical advantages compared to other treatments for both periodontitis and related systematic diseases.

SCI

英语

通讯

National Natural Science Foundation of China[81400561][21761142006] ; Tribology Science Fund of State Key Laboratory of Tribology[SKLTKF19B11]

Chemistry

Chemistry, Multidisciplinary

WOS:000558752000017

AMER CHEMICAL SOC

Web of Science

1.Peking Univ Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China
2.Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China
3.Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
4.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China
5.Peking Univ Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China

Zhang, Mengqi,Liu, Xiaomo,Xie, Yangzhouyun,et al. Biological Safe Gold Nanoparticle-Modified Dental Aligner Prevents the Porphyromonas gingivalis Biofilm Formation[J]. ACS Omega,2020,5(30):18685-18692.

Zhang, Mengqi.,Liu, Xiaomo.,Xie, Yangzhouyun.,Zhang, Qian.,Zhang, Wei.,...&Lin, Jiuxiang.(2020).Biological Safe Gold Nanoparticle-Modified Dental Aligner Prevents the Porphyromonas gingivalis Biofilm Formation.ACS Omega,5(30),18685-18692.

Zhang, Mengqi,et al."Biological Safe Gold Nanoparticle-Modified Dental Aligner Prevents the Porphyromonas gingivalis Biofilm Formation".ACS Omega 5.30(2020):18685-18692.