Aggregation-Induced Emission Luminogens Married to 2D Black Phosphorus Nanosheets for Highly Efficient Multimodal Theranostics

Huang, Jiachang1,2,3; He, Benzhao3; Zhang, Zhijun1,2; Li, Youmei1,2; Kang, Miaomiao1,2; Wang, Yuanwei1,2; Li, Kai4; Wang, Dong1; Tang, Ben Zhong3

2020-08-06

10.1002/adma.202003382

ADVANCED MATERIALS   影响因子和分区

0935-9648

1521-4095

Inspired by the respective advantages of aggregation-induced emission (AIE)-active photosensitizers and black phosphorus nanomaterials in cancer treatment, the facile construction of novel AIE photosensitizers married to 2D black phosphorus nanosheets and their application for multimodal theranostics are demonstrated. The developed nanomaterial simultaneously possesses distinctive properties and multiple functions including excellent stability, good biocompatibility, intensive fluorescence emission in the NIR region, high-performance reactive oxygen species generation, good photothermal conversion efficiency, outstanding cellular uptake, and effective accumulation at the tumor site. Both in vitro and in vivo evaluation show that the presented nanotheranostic system is an excellent candidate for NIR fluorescence-photothermal dual imaging-guided synergistic photodynamic-photothermal therapies. This study thus not only extends the applications scope of AIE and black phosphorus materials, but also offers useful insights into designing a new generation of cancer theranostic protocol for potential clinical applications.

aggregation-induced emission black phosphorus nanosheets cancer theranostics dual-modal imaging synergistic therapy

SCI ; EI

英语

NI论文

其他

China Postdoctoral Science Foundation[2019M663066] ; Natural Science Foundation for Distinguished Young Scholars of Guangdong Province[2020B1515020011] ; Natural Science Foundation of China[21801169] ; Science and Technology Foundation of Shenzhen City[JCYJ20190808153415062] ; Natural Science Foundation of Guangdong Province[2018A0303130081] ; Natural Science Foundation of Shenzhen University[2019004]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000555848600001

WILEY-V C H VERLAG GMBH

20203209018082

Phosphorus ; Infrared devices ; Photosensitizers ; Biocompatibility ; Fluorescence ; Nanostructured materials ; Diseases

Immunology:461.9.1 ; Light/Optics:741.1 ; Nanotechnology:761 ; Chemical Products Generally:804 ; Solid State Physics:933 ; Crystalline Solids:933.1

MATERIALS SCIENCE

Web of Science

1.Shenzhen Univ, Coll Mat Sci & Engn, Ctr AIE Res, Shenzhen 518060, Peoples R China
2.Shenzhen Univ, Coll Phys & Optoelect Engn, Key Lab Optoelect Devices & Syst, Shenzhen 518060, Peoples R China
3.Hong Kong Univ Sci & Technol, Dept Chem, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Hong Kong Branch,Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China
4.Southern Univ Sci & Technol SUSTech, SUSTech Acad Adv Interdisciplinary Studies, Dept Biomed Engn, Shenzhen 518055, Peoples R China

Huang, Jiachang,He, Benzhao,Zhang, Zhijun,et al. Aggregation-Induced Emission Luminogens Married to 2D Black Phosphorus Nanosheets for Highly Efficient Multimodal Theranostics[J]. ADVANCED MATERIALS,2020,32(37).

Huang, Jiachang.,He, Benzhao.,Zhang, Zhijun.,Li, Youmei.,Kang, Miaomiao.,...&Tang, Ben Zhong.(2020).Aggregation-Induced Emission Luminogens Married to 2D Black Phosphorus Nanosheets for Highly Efficient Multimodal Theranostics.ADVANCED MATERIALS,32(37).

Huang, Jiachang,et al."Aggregation-Induced Emission Luminogens Married to 2D Black Phosphorus Nanosheets for Highly Efficient Multimodal Theranostics".ADVANCED MATERIALS 32.37(2020).