Longitudinal changes of liver function and hepatitis B reactivation in COVID-19 patients with pre-existing chronic hepatitis B virus infection

Liu, Jiaye1; Wang, Tingyan2; Cai, Qingxian1; Sun, Liqin; Huang, Deliang1; Zhou, Guangde1; He, Qing1; Wang, Fu-Sheng3; Liu, Lei1; Chen, Jun1

2020-08-29

10.1111/hepr.13553

HEPATOLOGY RESEARCH   影响因子和分区

1386-6346

1872-034X

Aim With the current coronavirus disease (COVID-19) pandemic and high endemic levels of chronic hepatitis B virus (HBV) infection worldwide, it is urgent to investigate liver function changes of COVID-19 patients with chronic HBV infection, and how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in turn affects the course of chronic HBV infection. Method We undertook a retrospective study based on 347 COVID-19 patients (21 vs. 326 with vs. without chronic HBV infection). With the propensity score matching (PSM) method, we yielded 20 and 51 matched patients for the HBV group and the non-HBV group, respectively. Results At the end of follow-up, all of these 71 patients achieved SARS-CoV-2 clearance (P = 0.1). During the follow-up, 30% versus 31.4% in the HBV group versus non-HBV group progressed to severe COVID-19 (P = 0.97). After PSM, the longitudinal changes of median values for liver biochemistries were not significantly different between the two groups. In the HBV group versus non-HBV group, 35% (7/20) versus 37.25% (19/51) (P = 0.86) had abnormal alanine aminotransferase at least once during hospitalization, 30% (6/20) versus 31.37% (16/51) had abnormal aspartate aminotransferase (P = 0.91), 40% (8/20) versus 37.25% (19/51) had abnormal gamma-glutamyltransferase (P = 0.83), and 45% (9/20) versus 39.22% (20/51) had abnormal total bilirubin levels (P = 0.91). Moreover, three patients in the HBV group had hepatitis B reactivation. Conclusions Liver dysfunction presented in COVID-19 patients with/without chronic HBV. Moreover, those COVID-19 patients co-infected with chronic HBV could have a risk of hepatitis B reactivation. It is necessary to monitor liver function of COVID-19 patients, as well as HBV-DNA levels for those co-infected with HBV during the whole disease course.

COVID-19 HBV hepatitis B reactivation liver function

SCI

英语

第一 ; 通讯

National Natural Science Foundation of China[81803299] ; China Postdoctoral Science Foundation[2019M660840] ; Sanming Project of Medicine in Shenzhen[SZSM201612014]

Gastroenterology & Hepatology

Gastroenterology & Hepatology

WOS:000564583900001

WILEY

CLINICAL MEDICINE

Web of Science

1.Southern Univ Sci & Technol, Natl Clin Res Ctr Infect Dis, Peoples Hosp Shenzhen 3, Affiliated Hosp 2, Shenzhen, Peoples R China
2.Peoples Liberat Army Gen Hosp, Treatment & Res Ctr Infect Dis, Med Ctr 5, Beijing, Peoples R China
3.Univ Oxford, Nuffield Dept Med, Medawar Bldg Pathogen Res, Oxford, England

Liu, Jiaye,Wang, Tingyan,Cai, Qingxian,et al. Longitudinal changes of liver function and hepatitis B reactivation in COVID-19 patients with pre-existing chronic hepatitis B virus infection[J]. HEPATOLOGY RESEARCH,2020.

Liu, Jiaye.,Wang, Tingyan.,Cai, Qingxian.,Sun, Liqin.,Huang, Deliang.,...&Chen, Jun.(2020).Longitudinal changes of liver function and hepatitis B reactivation in COVID-19 patients with pre-existing chronic hepatitis B virus infection.HEPATOLOGY RESEARCH.

Liu, Jiaye,et al."Longitudinal changes of liver function and hepatitis B reactivation in COVID-19 patients with pre-existing chronic hepatitis B virus infection".HEPATOLOGY RESEARCH (2020).