TRIM22 inhibits respiratory syncytial virus replication by targeting JAK-STAT1/2 signaling

Wang, Yishu1,2; Chen, Yiling1; Lin, Ying1; Quan, Yingqin1; Xiao, Xiaoping1,3; Zhang, Renli1

2020-09-28

10.1002/jmv.26436

JOURNAL OF MEDICAL VIROLOGY   影响因子和分区

0146-6615

1096-9071

Respiratory syncytial virus (RSV) infection is a major cause of lower respiratory tract disease. Although RSV causes major economic losses every year, effective treatments have not been found so far. Recent studies have shown that the tripartite motif-containing (TRIM) superfamily plays an essential role in the immune response. In this study, we found that TRIM22 had an inhibitory effect on RSV infection, and downregulation of TRIM22 moderately enhanced RSV replication. Our data further demonstrated that RSV infection induced TRIM22 expression through the activation of JAK-STAT1/2 signaling. RSV infection also induced TRIM22 expression. Taken together, these data points showed that the TRIM family member, TRIM22, had an essential role in resisting RSV infection, and this effect was closely related to the JAK-STAT1/2 pathway. Our results provide promising evidence for a novel target for the prevention and treatment of RSV.

interferon respiratory syncytial virus TRIM22

SCI

英语

其他

Shenzhen San-Ming Project for prevention and research on vector-borne diseases[SZSM201611064] ; National Natural Science Foundation of China[31700148]

Virology

Virology

WOS:000573019000001

WILEY

MICROBIOLOGY

Web of Science

1.Shenzhen Ctr Dis Control & Prevent, Inst Pathogen Organisms, Shenzhen 518055, Guangdong, Peoples R China
2.Southern Univ Sci & Technol SUSTech, Dept Biol, Shenzhen, Peoples R China
3.Tsinghua Univ, Sch Med, Tsinghua Peking Joint Ctr Life Sci, Beijing, Peoples R China

Wang, Yishu,Chen, Yiling,Lin, Ying,et al. TRIM22 inhibits respiratory syncytial virus replication by targeting JAK-STAT1/2 signaling[J]. JOURNAL OF MEDICAL VIROLOGY,2020,93(6).

Wang, Yishu,Chen, Yiling,Lin, Ying,Quan, Yingqin,Xiao, Xiaoping,&Zhang, Renli.(2020).TRIM22 inhibits respiratory syncytial virus replication by targeting JAK-STAT1/2 signaling.JOURNAL OF MEDICAL VIROLOGY,93(6).

Wang, Yishu,et al."TRIM22 inhibits respiratory syncytial virus replication by targeting JAK-STAT1/2 signaling".JOURNAL OF MEDICAL VIROLOGY 93.6(2020).