Catalytic mutual multicomponent reaction: facile access to alpha-trifluoromethylthiolated ketones

Jin, Ming Yu1,2; Gu, Xiaodong1,2; Deng, Min1,2; Wang, Chuancheng1,2; Wang, Jun (Joelle)1,2,3

2020-09-16

10.1039/d0cc04555a

CHEMICAL COMMUNICATIONS   影响因子和分区

1359-7345

1364-548X

A multicomponent catalytic reaction between ketones, Morita-Baylis-Hillman (MBH) carbonates and trifluoromethylthiolating agents is devised for straightforwardly accessing two products, alpha-trifluoromethylthiolated ketones and alpha-methylene beta-amino esters in a one pot fashion. Particularly noteworthy is that the trifluoromethylthiolating reagent is employed as both the nitrogen and SCF(3)source initiated by DABCO. This mild one pot strategy enjoys atom- and step-economic attractiveness, for direct introduction of an SCF(3)group onto a variety of acyclic ketones, which have been considered as less effective and less developed substrates.

MORITA-BAYLIS-HILLMAN ASYMMETRIC ALLYLIC AMINATION ELECTROPHILIC TRIFLUOROMETHYLTHIOLATION NUCLEOPHILIC TRIFLUOROMETHYLTHIOLATION ENANTIOSELECTIVE TRIFLUOROMETHYLTHIOLATION ADDUCTS REAGENT ACIDS 2ND-GENERATION CARBONATES

SCI ; EI ; IC ; CCR

英语

NI论文

第一 ; 通讯

Guangdong Innovative Program[2019BT02Y335]

Chemistry

Chemistry, Multidisciplinary

WOS:000567648500026

ROYAL SOC CHEMISTRY

20203909221626

Catalysis ; Rate constants

Chemical Reactions:802.2 ; Organic Compounds:804.1

CHEMISTRY

Web of Science

1.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Guangdong, Peoples R China;
2.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China;
3.Hong Kong Baptist Univ, Dept Chem, Kowloon, Hong Kong, Peoples R China

Jin, Ming Yu,Gu, Xiaodong,Deng, Min,et al. Catalytic mutual multicomponent reaction: facile access to alpha-trifluoromethylthiolated ketones[J]. CHEMICAL COMMUNICATIONS,2020,56(72):10552-10555.

Jin, Ming Yu,Gu, Xiaodong,Deng, Min,Wang, Chuancheng,&Wang, Jun .(2020).Catalytic mutual multicomponent reaction: facile access to alpha-trifluoromethylthiolated ketones.CHEMICAL COMMUNICATIONS,56(72),10552-10555.

Jin, Ming Yu,et al."Catalytic mutual multicomponent reaction: facile access to alpha-trifluoromethylthiolated ketones".CHEMICAL COMMUNICATIONS 56.72(2020):10552-10555.