Controversial treatments: An updated understanding of the coronavirus disease 2019

Zhang, Cantong1; Huang, Shaoying1; Zheng, Fengping1; Dai, Yong1,2

2020-09

10.1002/jmv.25788

JOURNAL OF MEDICAL VIROLOGY   影响因子和分区

0146-6615

1096-9071

An outbreak of severe acute respiratory syndrome-related coronavirus 2 infection has posed significant threats to international health and the economy. In the absence of specific treatment for this virus, there is an urgent need to learn from the experience and lessons in China. To reduce the case-fatality rate among coronavirus disease 2019 patients, we should not ignore the complications, such as RNAaemia, acute respiratory distress syndrome, and multiple organ dysfunction. To help understand the advantages and limitations of differential treatments, we provide a timely review and discuss the complications and corresponding major treatments, especially controversial ones such as antiviral therapy (remdesivir, ribavirin, and chloroquine), glucocorticoid therapy, extracorporeal support including an artificial liver system, and extracorporeal membrane oxygenation based on available evidence. As a result, we suggest that antiviral therapy and organ function support are vital to reduce mortality for mild patients and critical patients, respectively.

coronavirus ACUTE RESPIRATORY SYNDROME COVID-19 INFLUENZA-A H7N9 literature review IN-VITRO pneumonia CORTICOSTEROID TREATMENT SARS-CoV-2 SARS CORONAVIRUS treatment RIBAVIRIN REPLICATION CHLOROQUINE INHIBITION VIRUS

SCI

英语

ESI高被引

第一 ; 通讯

Virology

Virology

WOS:000560044500031

WILEY

MICROBIOLOGY

Web of Science

1.Southern Univ Sci & Technol, Dept Clin Med Res Ctr, Clin Med Coll 2, Shenzhen Peoples Hosp,Jinan Univ,Affiliated Hosp, Shenzhen 518020, Guangdong, Peoples R China;
2.Guangxi Key Lab Metab Dis Res, Dept Nephrol, Guilin, Peoples R China

Zhang, Cantong,Huang, Shaoying,Zheng, Fengping,et al. Controversial treatments: An updated understanding of the coronavirus disease 2019[J]. JOURNAL OF MEDICAL VIROLOGY,2020,92(9):1441-1448.

Zhang, Cantong,Huang, Shaoying,Zheng, Fengping,&Dai, Yong.(2020).Controversial treatments: An updated understanding of the coronavirus disease 2019.JOURNAL OF MEDICAL VIROLOGY,92(9),1441-1448.

Zhang, Cantong,et al."Controversial treatments: An updated understanding of the coronavirus disease 2019".JOURNAL OF MEDICAL VIROLOGY 92.9(2020):1441-1448.