Preparation and Characterization of PHBV/PEO/AZ-Gelatin Electrospun Mats with Photochemical Surface Modification: The Role of AZ-Gelatin

Xu, Yongjing1; Lu, Hongwei2; Sun, Chenkai1; Zou, Liming1; Yin, Hai1; Li, Wengang1

2020-08-11

10.1002/mame.202000344

MACROMOLECULAR MATERIALS AND ENGINEERING   影响因子和分区

1438-7492

1439-2054

As ideal tissue engineering scaffold, surface feature plays an important role in cell adhesion and proliferation. In order to improve cytocompatibility of poly(3-hydroxybutyrate-co-hydroxyvalerate) (PHBV) and polyethylene oxide (PEO) synthetic materials, in this study, photochemical surface modification is applied in electrospinning field for the first time. Azidobenzoic acid-modified gelatin (AZ-gelatin) as bioactive protein is successfully fixed on PHBV/PEO electrospun mats by photochemical technique without any crosslinking agent. In vitro degradation and cell culture results show that PHBV/PEO/AZ-gelatin electrospun mats have excellent cell adhesion and proliferation compared with PHBV and PHBV/PEO electrospun mats. But, by contrast with PHBV/PEO electrospun mats, the fiber diameter of PHBV/PEO/AZ-gelatin mats increased, and the porosity and mechanical properties decrease. Nonetheless, PHBV/PEO/AZ-gelatin-0.01 mg mL(-1) electrospun mats have shown better morphology (fiber diameter 600 nm, porosity 88%), mechanical properties (4.2 MPa), and water vapor transmission rate (2301 g m(-2)day(-1)), which has great potential as artificial skin scaffold in tissue regeneration field.

AZ-gelatin SCAFFOLDS PHBV NANOFIBERS PEO FABRICATION AZ-gelatin electrospun mats IMMOBILIZATION photochemical surface modification HYDROGEL SOLVENT PLA

SCI ; EI

英语

其他

National Key R&D Program of China[2016YFB0303200]

Materials Science ; Polymer Science

Materials Science, Multidisciplinary ; Polymer Science

WOS:000558199600001

WILEY-V C H VERLAG GMBH

20203309044397

Cells ; Cell adhesion ; Tissue ; Biodegradation ; Tissue regeneration ; Cell culture ; Morphology ; Scaffolds (biology) ; Porosity ; Biomechanics ; Cell engineering

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Biomechanics, Bionics and Biomimetics:461.3 ; Biotechnology:461.8 ; Biology:461.9 ; Biochemistry:801.2 ; Organic Polymers:815.1.1 ; Physical Properties of Gases, Liquids and Solids:931.2 ; Materials Science:951

MATERIALS SCIENCE

Web of Science

1.Donghua Univ, Coll Mat Sci & Engn, State Key Lab Modificat Chem Fibers & Polymer Mat, 2999 North People Rd, Shanghai 201620, Peoples R China;
2.Southern Univ Sci & Technol, Dept Mat Sci & Engn, 1088 Xueyuan Blvd, Shenzhen 518055, Guangdong, Peoples R China

Xu, Yongjing,Lu, Hongwei,Sun, Chenkai,et al. Preparation and Characterization of PHBV/PEO/AZ-Gelatin Electrospun Mats with Photochemical Surface Modification: The Role of AZ-Gelatin[J]. MACROMOLECULAR MATERIALS AND ENGINEERING,2020,305(10).

Xu, Yongjing,Lu, Hongwei,Sun, Chenkai,Zou, Liming,Yin, Hai,&Li, Wengang.(2020).Preparation and Characterization of PHBV/PEO/AZ-Gelatin Electrospun Mats with Photochemical Surface Modification: The Role of AZ-Gelatin.MACROMOLECULAR MATERIALS AND ENGINEERING,305(10).

Xu, Yongjing,et al."Preparation and Characterization of PHBV/PEO/AZ-Gelatin Electrospun Mats with Photochemical Surface Modification: The Role of AZ-Gelatin".MACROMOLECULAR MATERIALS AND ENGINEERING 305.10(2020).