南方科技大学知识苑(SUSTech KC): Influence of preoperative radiotherapy on head and neck free-flap reconstruction: Systematic review and meta-analysis

题名	Influence of preoperative radiotherapy on head and neck free-flap reconstruction: Systematic review and meta-analysis
作者	Mijiti, Ainiwaer 1; Kuerbantayi, Nazuke 2; Zhang, Zhi Q.3; Su, Ming Y.1; Zhang, Xiao H.1; Huojia, Muhetaer 1
通讯作者	Huojia, Muhetaer
发表日期	2020-08
DOI	10.1002/hed.26136
发表期刊	HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 影响因子和分区
ISSN	1043-3074
EISSN	1097-0347
卷号	42 期号:8页码:2165-2180
摘要	The effect of preoperative external radiotherapy (XRT) on head and neck free-flap reconstruction is still controversial. In this study, we aimed to determine the impact of preoperative XRT on the outcomes of head and neck microvascular free-flap reconstruction. A systematic review and meta-analysis was conducted in concordance with the Systematic reviews and Meta-Analyses protocol. We searched several databases (PubMed, EMBASE, Web of Science, and Cochrane Library) to find published papers on the topic. The R program was used for data synthesis and statistical heterogeneity evaluation; then, fixed effect or random effect models were used. A total of 37 studies, involving 12 408 patients with 12 668 flaps, were included in this meta-analysis. The overall flap success rate for all studies was 94.4%. Pooled analysis showed that patients with preoperative XRT were significantly associated with an increased risk of total flap failure (odds ratio [OR] = 1.80, 95% confidence interval [CI] = 1.45-2.23,P < .001), partial flap failure (OR = 1.90, 95% CI = 1.07-3.38,P = .029), and postoperative complication rates (OR = 2.22, 95% CI = 1.64-2.72,P < .001). Our study suggests that preoperative XRT is associated with an increased risk of developing free-flap failure and an increased postoperative complication rate.
关键词	complications FREE TISSUE TRANSFER head and neck tumor RISK-FACTORS meta-analysis MICROVASCULAR RECONSTRUCTION microvascular free flaps POSTOPERATIVE COMPLICATIONS radiotherapy MICROSURGICAL HEAD RADIATION-THERAPY CANCER-PATIENTS OUTCOMES FAILURE SURGERY
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
WOS研究方向	Otorhinolaryngology ; Surgery
WOS类目	Otorhinolaryngology ; Surgery
WOS记录号	WOS:000549552800052
出版者	WILEY
ESI学科分类	CLINICAL MEDICINE
来源库	Web of Science
引用统计	被引频次[WOS]：32
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/187761
专题	南方科技大学医学院
作者单位	1.Shenzhen Univ, Affiliated Luohu Hosp, Dept Oral & Maxillofacial Surg, Shenzhen 518000, Peoples R China; 2.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China; 3.Shenzhen Univ, Affiliated Luohu Hosp, Dept Stomatol, Shenzhen, Peoples R China
推荐引用方式 GB/T 7714	Mijiti, Ainiwaer,Kuerbantayi, Nazuke,Zhang, Zhi Q.,et al. Influence of preoperative radiotherapy on head and neck free-flap reconstruction: Systematic review and meta-analysis[J]. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK,2020,42(8):2165-2180.
APA	Mijiti, Ainiwaer,Kuerbantayi, Nazuke,Zhang, Zhi Q.,Su, Ming Y.,Zhang, Xiao H.,&Huojia, Muhetaer.(2020).Influence of preoperative radiotherapy on head and neck free-flap reconstruction: Systematic review and meta-analysis.HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK,42(8),2165-2180.
MLA	Mijiti, Ainiwaer,et al."Influence of preoperative radiotherapy on head and neck free-flap reconstruction: Systematic review and meta-analysis".HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 42.8(2020):2165-2180.