Cardiac manifestations of COVID-19 in Shenzhen, China

Zeng, Jia-Hui1; Wu, Wei-Bo2; Qu, Jiu-Xin3; Wang, Yao1; Dong, Chang-Feng1; Luo, Yong-Fang1; Zhou, Dan1; Feng, Wen-Xia1; Feng, Cheng1

2020-07-28

10.1007/s15010-020-01473-w

INFECTION   影响因子和分区

0300-8126

1439-0973

Purpose The coronavirus disease 2019 (COVID-19) outbreak has become a global public health concern; however, relatively few detailed reports of related cardiac injury are available. The aims of this study were to compare the clinical and echocardiographic characteristics of inpatients in the intensive-care unit (ICU) and non-ICU patients. Methods We recruited 416 patients diagnosed with COVID-19 and divided them into two groups: ICU (n = 35) and non-ICU (n = 381). Medical histories, laboratory findings, and echocardiography data were compared. Results The levels of myocardial injury markers in ICU vs non-ICU patients were as follows: troponin I (0.029 ng/mL [0.007-0.063] vs 0.006 ng/mL [0.006-0.006]) and myoglobin (65.45 mu g/L [39.77-130.57] vs 37.00 mu g/L [26.40-53.54]). Echocardiographic findings included ventricular wall thickening (12 [39%] vs 1 [4%]), pulmonary hypertension (9 [29%] vs 0 [0%]), and reduced left-ventricular ejection fraction (5 [16%] vs 0 [0%]). Overall, 10% of the ICU patients presented with right heart enlargement, thickened right-ventricular wall, decreased right heart function, and pericardial effusion. Cardiac complications were more common in ICU patients, including acute cardiac injury (21 [60%] vs 13 [3%]) (including 2 cases of fulminant myocarditis), atrial or ventricular tachyarrhythmia (3 [9%] vs 3 [1%]), and acute heart failure (5 [14%] vs 0 [0%]). Conclusion Myocardial injury marker elevation, ventricular wall thickening, pulmonary artery hypertension, and cardiac complications including acute myocardial injury, arrhythmia, and acute heart failure are more common in ICU patients with COVID-19. Cardiac injury in COVID-19 patients may be related more to the systemic response after infection rather than direct damage by coronavirus.

COVID-19 CORONAVIRUS Coronavirus DYSFUNCTION Myocarditis WUHAN Echocardiography Intensive-care unit

SCI

英语

第一 ; 通讯

Guangdong Medical Research Fund[B2019163]

Infectious Diseases

Infectious Diseases

WOS:000555548600003

SPRINGER HEIDELBERG

IMMUNOLOGY

Web of Science

1.Southern Univ Sci & Technol, Hosp 2, Dept Med Ultrason,Natl Clin Res Ctr Infect Dis, State Key Discipline Infect Dis,Shenzhen Peoples, 29 Bulan Rd, Shenzhen 518112, Peoples R China;
2.Southern Univ Sci & Technol, Hosp 2, Dept Infect Dis,Natl Clin Res Ctr Infect Dis, State Key Discipline Infect Dis,Shenzhen Peoples, 29 Bulan Rd, Shenzhen 518112, Peoples R China;
3.Southern Univ Sci & Technol, Hosp 2, Dept Clin Lab,Natl Clin Res Ctr Infect Dis, State Key Discipline Infect Dis,Shenzhen Peoples, 29 Bulan Rd, Shenzhen 518112, Peoples R China

Zeng, Jia-Hui,Wu, Wei-Bo,Qu, Jiu-Xin,et al. Cardiac manifestations of COVID-19 in Shenzhen, China[J]. INFECTION,2020,48(6).

Zeng, Jia-Hui.,Wu, Wei-Bo.,Qu, Jiu-Xin.,Wang, Yao.,Dong, Chang-Feng.,...&Feng, Cheng.(2020).Cardiac manifestations of COVID-19 in Shenzhen, China.INFECTION,48(6).

Zeng, Jia-Hui,et al."Cardiac manifestations of COVID-19 in Shenzhen, China".INFECTION 48.6(2020).