Efficient Synthesis of Chiral Drugs Facilated by P-Chiral Phosphorus Ligands

Xu Ronghua1; Yang He3; Tang Wenjun1,2,4

2020-06-25

10.6023/cjoc202003015

CHINESE JOURNAL OF ORGANIC CHEMISTRY   影响因子和分区

0253-2786

Development of efficient and practical asymmetric catalytic reactions plays a pivotal role for the concise syntheses of chiral drugs. Chiral ligands and catalysts are crucial for the selectivity and reactivity of the catalytic reactions. In this account, the design and development of a series of P-chiral mono- and bis-phosphorus ligands were summarized based on a benzooxaphosphane backbone and their applications in the synthesis of chiral drugs. Beside their P-chirality, these ligands are structurally rigid, sterically bulky, and electron-rich, providing good physical properties and tunabilities. Facilitated by these chiral ligands, a series of efficient and practical reactions including asymmetric hydrogenation, asymmetric cross-coupling, asymmetric cyclization, and asymmetric nucleophilic additions have been developed. The excellent conversions, yields, regioselectivities, enantioselectivities, and broad substrate scope have enabled concise and efficient syntheses of a series of chiral drugs.

chiral phosphorus ligands HYDROGENATION transition metal catalysis DERIVATIVES asymmetric synthesis CONCISE enantioselectivity DESIGN chiral drugs

SCI

中文

其他

Chemistry

Chemistry, Organic

WOS:000560811400001

SCIENCE PRESS

CHEMISTRY

1.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China;
3.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Guangdong, Peoples R China;
4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Chem & Mat Sci, Hangzhou 310024, Peoples R China

Xu Ronghua,Yang He,Tang Wenjun. Efficient Synthesis of Chiral Drugs Facilated by P-Chiral Phosphorus Ligands[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2020,40(6):1409-1422.

Xu Ronghua,Yang He,&Tang Wenjun.(2020).Efficient Synthesis of Chiral Drugs Facilated by P-Chiral Phosphorus Ligands.CHINESE JOURNAL OF ORGANIC CHEMISTRY,40(6),1409-1422.

Xu Ronghua,et al."Efficient Synthesis of Chiral Drugs Facilated by P-Chiral Phosphorus Ligands".CHINESE JOURNAL OF ORGANIC CHEMISTRY 40.6(2020):1409-1422.