Nano-Platelets as an Oxygen Regulator for Augmenting Starvation Therapy Against Hypoxic Tumor

Huang，Chunyu1,2; Zhu，Chang1; Chen，Jie1; Huang，Kaibin1; Li，Fang1; Ding，Shunkai1; Xia，Ligang1; Jiang，Wei3; Li，Yang1

2020-09-04

10.3389/fbioe.2020.571993

Frontiers in Bioengineering and Biotechnology   影响因子和分区

2296-4185

2296-4185

The restriction of a tumor’s energy supply is proven to be an effective means of treatment. Glucose oxidase (GOx), an enzyme that catalyzes the conversion of glucose to glucolactone, producing oxygen and hydrogen peroxide in the process, has proved useful in this regard. However, hypoxia, which is implicated in tumor growth, has been found to mediate resistance to this type of tumor starvation. Here, we describe the design and testing of a platelet membrane mimetic, PMS, consisting of mesoporous silica nanoparticles (MSNs) loaded with metformin (MET) as an inner layer and platelet membranes (PM) as an outer layer that inhibits oxygen consumption by the tumor cells’ respiratory pathways and enhances the effectiveness of GOx. MET directly inhibits the activity of complex I in mitochondrial electron transport and is thus a potent inhibitor of cell respiration. PMS target tumor tissue effectively and, once internalized, MET can inhibit respiration. When oxygen is plentiful, GOx promotes glucose consumption, allowing amplification of its effects on tumor starvation. This combination of respiratory suppression by PMS and starvation therapy by GOx has been found to be effective in both targeting tumors and inhibiting their growth. It is hoped that this strategy will shed light on the development of next-generation tumor starvation treatments.

glucose oxidase metformin platelet membrane respiratory suppression starvation therapy

SCI ; EI

英语

第一 ; 通讯

National Nature Science Foundation of China[81901771][81901882] ; Science, Technology and Innovation Commission of Shenzhen Municipality[JCYJ20190807144 209381]

Biotechnology & Applied Microbiology ; Science & Technology - Other Topics

Biotechnology & Applied Microbiology ; Multidisciplinary Sciences

WOS:000573804800001

FRONTIERS MEDIA SA

2-s2.0-85091238551

Scopus

1.Department of Gastrointestinal Surgery,Shenzhen People’s Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,China
2.Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education,School of Physics and Technology,Wuhan University,Wuhan,China
3.Center for Precision Medicine,The Second Affiliated Hospital of Zhengzhou University,Academy of Medical Sciences,Zhengzhou University,Zhengzhou,China

Huang，Chunyu,Zhu，Chang,Chen，Jie,et al. Nano-Platelets as an Oxygen Regulator for Augmenting Starvation Therapy Against Hypoxic Tumor[J]. Frontiers in Bioengineering and Biotechnology,2020,8.

Huang，Chunyu.,Zhu，Chang.,Chen，Jie.,Huang，Kaibin.,Li，Fang.,...&Li，Yang.(2020).Nano-Platelets as an Oxygen Regulator for Augmenting Starvation Therapy Against Hypoxic Tumor.Frontiers in Bioengineering and Biotechnology,8.

Huang，Chunyu,et al."Nano-Platelets as an Oxygen Regulator for Augmenting Starvation Therapy Against Hypoxic Tumor".Frontiers in Bioengineering and Biotechnology 8(2020).