Nanorobots-assisted tumor sensitization and targeting for multifocal tumor

We have proposed a new tumor sensitization and targeting (TST) framework, named in vivo computation, in our previous investigations. Our previous works are focusing on the TST for unifocal tumor, where we proposed the weak priority evolution strategy to adapt to the actuating mode of the homogeneous magnetic field used in the state-of-the-art nanorobotic platforms, and some in vitro validations were performed. In this paper, we focus on the problem of TST for multifocal tumor, which can be seen as a multimodal optimization problem for in vivo computation. To overcome this issue, we propose a sequential targeting strategy to complete TST for the lesions one by one with the assistance of nanorobot swarms. The proposed tumor targeting strategy is performed in the in vitro experiment, where Janus particles are used as nanorobots and a 2-D microchannel network plays the role of the tumor vascular network. This paper describes the theoretical knowledge, experimental validation scenario and shows the experimental result on the targeting efficiency by using the proposed targetlng strategy.