An NIR-II-Emissive Photosensitizer for Hypoxia-Tolerant Photodynamic Theranostics

Li，Lanqing1; Shao，Chen1; Liu，Tao2; Chao，Zhicong1; Chen，Huanle1; Xiao，Fan1; He，Huamei1; Wei，Zixiang1; Zhu，Yulin2; Wang，Huan2,3; Zhang，Xindan1; Wen，Yating4; Yang，Bing4; He，Feng2; Tian，Leilei1

2020

10.1002/adma.202003471

ADVANCED MATERIALS   影响因子和分区

0935-9648

1521-4095

As a common feature in a majority of malignant tumors, hypoxia has become the Achilles’ heel of photodynamic therapy (PDT). The development of type-I photosensitizers that show hypoxia-tolerant PDT efficiency provides a straightforward way to address this issue. However, type-I PDT materials have rarely been discovered. Herein, a π-conjugated molecule with A–D–A configuration, COi6-4Cl, is reported. The HO-dispersible nanoparticle of COi6-4Cl can be activated by an 880 nm laser, and displays hypoxia-tolerant type I/II combined PDT capability, and more notably, a high NIR-II fluorescence with a quantum yield over 5%. Moreover, COi6-4Cl shows a negligible photothermal conversion effect. The non-radiative decay of COi6-4Cl is suppressed in the dispersed and aggregated state due to the restricted molecular vibrations and distinct intermolecular steric hindrance induced by its four bulky side chains. These features make COi6-4Cl a distinguished single-NIR-wavelength-activated phototheranostic material, which performs well in NIR-II fluorescence-guided PDT treatment and shows an enhanced in vivo anti-tumor efficiency over the clinically approved Chlorin e6, by the equal stresses on hypoxia-tolerant anti-tumor therapy and deep-penetration imaging. Therefore, the great potential of COi6-4Cl in precise PDT cancer therapy against hypoxia challenges is demonstrated.

NIR-II fluorescence photodynamic theranostics tumor hypoxia type-I photodynamic therapy

SCI ; EI

英语

NI论文

第一 ; 通讯

National Natural Science Foundation of China[51973089] ; Shenzhen Fundamental Research Programs[JCYJ20160226193029593][JCYJ20170817105645935] ; Shenzhen Science and Technology Innovation Commission[KQTD20170810111314625] ; Guangdong Innovative and Entrepreneurial Research Team Program[2016ZT06G587] ; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000575806800001

WILEY-V C H VERLAG GMBH

20204109324694

Efficiency ; Photosensitizers ; Tumors ; Chlorine compounds ; Fluorescence ; Infrared devices

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Light/Optics:741.1 ; Production Engineering:913.1

MATERIALS SCIENCE

2-s2.0-85092200327

Scopus

1.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,1088 Xueyuan Blvd., Nanshan District,518055,China
2.Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,Shenzhen,1088 Xueyuan Blvd., Nanshan District,518055,China
3.Faculty of Health Sciences,University of Macau,999078,Macao
4.State Key Laboratory of Supramolecular Structure and Materials,College of Chemistry,Jilin University,Changchun,2699 Qianjin Avenue,130012,China

Li，Lanqing,Shao，Chen,Liu，Tao,et al. An NIR-II-Emissive Photosensitizer for Hypoxia-Tolerant Photodynamic Theranostics[J]. ADVANCED MATERIALS,2020,32(45).

Li，Lanqing.,Shao，Chen.,Liu，Tao.,Chao，Zhicong.,Chen，Huanle.,...&Tian，Leilei.(2020).An NIR-II-Emissive Photosensitizer for Hypoxia-Tolerant Photodynamic Theranostics.ADVANCED MATERIALS,32(45).

Li，Lanqing,et al."An NIR-II-Emissive Photosensitizer for Hypoxia-Tolerant Photodynamic Theranostics".ADVANCED MATERIALS 32.45(2020).