A natural product solution to aging and aging-associated diseases

Yang, Chuanbin1,2; Zhang, Wei1,2,3; Dong, Xiaoduo1,2,3; Fu, Chunjin1,2; Yuan, Jimin1,2; Xu, Menglong5; Liang, Zhen1,2; Qiu, Chen2,4; Xu, Chengchao1,2,5

2020-12-01

10.1016/j.pharmthera.2020.107673

PHARMACOLOGY & THERAPEUTICS   影响因子和分区

0163-7258

Aging is a natural biological progress accompanied by the gradual decline in physiological functions, manifested by its close association with an increased incidence of human diseases and higher vulnerability to death. Those diseases include neurological disorders, cardiovascular diseases, diabetes, and cancer, many of which are currently without effective cures. Even though aging is inevitable, there are still interventions that can be developed to prevent/delay the onset and progression of those aging-associated diseases and extend healthspan and/or lifespan. Here, we review decades of research that reveals the molecular pathways underlying aging and forms the biochemical basis for anti-aging drug development. Importantly, due to the vast chemical space of natural products and the rich history of herb medicines in treating human diseases documented in different cultures, natural products have played essential roles in aging research. Using several of the most promising natural products and their derivatives as examples, we discuss how natural products serve as an inspiration resource that helped the identification of key components/pathways underlying aging, their mechanisms of action inside the cell, and the functional scaffolds or targeting mechanisms that can be learned from natural products for drug engineering and optimization. We argue that natural products might eventually provide a solution to aging and aging associated diseases. (C) 2020 Elsevier Inc. All rights reserved.

Natural products Aging Aging-associated diseases Longevity Mechanism of action (MOA) Anti-aging therapies

SCI

英语

通讯

Shenzhen Science and Technology Innovation Commission["JCYJ20190807145209306","JCYJ20190807145213180","JCYJ20140416180032316"] ; National Natural Science Foundation of China[81703487] ; Shenzhen Economic and Information Committee "Innovation Chain and Industry Chain" integration special support plan project[20180225112449943]

Pharmacology & Pharmacy

Pharmacology & Pharmacy

WOS:000594690000014

PERGAMON-ELSEVIER SCIENCE LTD

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Geriatr, Shenzhen 518020, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
3.Jinan Univ, Integrated Chinese & Western Med Postdoctoral Res, Guangzhou 510632, Peoples R China
4.Jinan Univ, Dept Resp & Crit Care Med, Shenzhen Peoples Hosp, Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China
5.Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Yang, Chuanbin,Zhang, Wei,Dong, Xiaoduo,et al. A natural product solution to aging and aging-associated diseases[J]. PHARMACOLOGY & THERAPEUTICS,2020,216.

Yang, Chuanbin.,Zhang, Wei.,Dong, Xiaoduo.,Fu, Chunjin.,Yuan, Jimin.,...&Xu, Chengchao.(2020).A natural product solution to aging and aging-associated diseases.PHARMACOLOGY & THERAPEUTICS,216.

Yang, Chuanbin,et al."A natural product solution to aging and aging-associated diseases".PHARMACOLOGY & THERAPEUTICS 216(2020).