Chloroquine and hydroxychloroquine in the treatment of malaria and repurposing in treating COVID-19

Lei，Zi Ning1; Wu，Zhuo Xun1; Dong，Shaowei2,3; Yang，Dong Hua1; Zhang，Litu4; Ke，Zunfu5; Zou，Chang2,3; Chen，Zhe Sheng1

2020

10.1016/j.pharmthera.2020.107672

PHARMACOLOGY & THERAPEUTICS   影响因子和分区

0163-7258

1879-016X

Chloroquine (CQ) and Hydroxychloroquine (HCQ) have been commonly used for the treatment and prevention of malaria, and the treatment of autoimmune diseases for several decades. As their new mechanisms of actions are identified in recent years, CQ and HCQ have wider therapeutic applications, one of which is to treat viral infectious diseases. Since the pandemic of the coronavirus disease 2019 (COVID-19), CQ and HCQ have been subjected to a number of in vitro and in vivo tests, and their therapeutic prospects for COVID-19 have been proposed. In this article, the applications and mechanisms of action of CQ and HCQ in their conventional fields of anti-malaria and anti-rheumatism, as well as their repurposing prospects in anti-virus are reviewed. The current trials and future potential of CQ and HCQ in combating COVID-19 are discussed.

Chloroquine (CQ) COVID-19 Hydroxychloroquine (HCQ) Malaria

SCI

英语

其他

2-s2.0-85091243748

Scopus

1.Department of Pharmaceutical Sciences,College of Pharmacy and Health Sciences,St. John's University,Queens,11439,United States
2.Key Laboratory of medical electrophysiology of education ministry,School of Pharmacy,Southwest Medical University,China
3.Shenzhen Public Service Platform on Tumor Precision Medicine and Molecular Diagnosis,Southern University of Science and Technology,Shenzhen,518020,China
4.Department of Research,Affiliated Tumor Hospital of Guangxi Medical University,Nanning,Guangxi Zhuang Autonomous Region,530021,China
5.Department of Pathology,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,510080,China

Lei，Zi Ning,Wu，Zhuo Xun,Dong，Shaowei,et al. Chloroquine and hydroxychloroquine in the treatment of malaria and repurposing in treating COVID-19[J]. PHARMACOLOGY & THERAPEUTICS,2020.

Lei，Zi Ning.,Wu，Zhuo Xun.,Dong，Shaowei.,Yang，Dong Hua.,Zhang，Litu.,...&Chen，Zhe Sheng.(2020).Chloroquine and hydroxychloroquine in the treatment of malaria and repurposing in treating COVID-19.PHARMACOLOGY & THERAPEUTICS.

Lei，Zi Ning,et al."Chloroquine and hydroxychloroquine in the treatment of malaria and repurposing in treating COVID-19".PHARMACOLOGY & THERAPEUTICS (2020).