Ningdong Granule Upregulates the Striatal DA Transporter and Attenuates Stereotyped Behavior of Tourette Syndrome in Rats

Li, Jijun1; Guo, Yi2; Zhao, Lin3; Sun, Kexing1; Xi, Guangjun4; Li, Zai-Wang2

2020-09-14

10.1155/2020/2980705

Evidence-based Complementary and Alternative Medicine   影响因子和分区

1741-427X

1741-4288

This study aimed to evaluate the possible mechanism of Ningdong granule (NDG) for the treatment of Tourette syndrome (TS). The rats with stereotyped behavior were established by microinjection with TS patients' sera; then, the model rats were divided into NDG and haloperidol (Hal) group, and the nonmedication model rats were regarded as treatment control (TS group). The stereotyped behavior of the rats was recorded, the level of dopamine (DA) in striatum, and the content of homovanillic acid (HVA) in sera were tested, and dopamine transporter (DAT) expression was measured in the study. The experimental results showed that NDG effectively inhibited the stereotyped behavior (P<0.01), decreased the levels of DA in the striatum (P<0.05), increased the content of sera HVA (P<0.01), and enhanced the protein and mRNA expression of DAT in the striatum (P<0.01). Additionally, the results also revealed Hal could improve the stereotyped behavior as well but had no remarkable influence on DAT expression and DA metabolism. In conclusion, NDG attenuates stereotyped behavior, and its mechanism of action might be associated with the upregulation of DAT expression to regulate DA metabolism in the brain.

SCI

英语

通讯

National Natural Science Foundation of China[81528023][81671219][81202724] ; Natural Science Foundation of Jiangsu Province[BK20151109] ; Shenzhen Special Fund for Basic Research (Shenzhen Natural Science Foundation)[JCYJ20190806145812589]

Integrative & Complementary Medicine

Integrative & Complementary Medicine

WOS:000576057800001

HINDAWI LTD

Web of Science

1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Dept Integrat Med Pediat, Shanghai 200127, Peoples R China
2.Southern Univ Sci & Technol, Jinan Univ, Affiiated Hosp 1, Shenzhen Peoples Hosp,Clin Med Coll 2,Dept Neurol, Shenzhen 518020, Peoples R China
3.Shandong Univ, Prov Hosp, Dept Integrat Med Pediat, Jinan 250021, Shandong, Peoples R China
4.Nanjing Med Univ, Wuxi Peoples Hosp, Dept Neurol, Wuxi 214023, Jiangsu, Peoples R China

Li, Jijun,Guo, Yi,Zhao, Lin,et al. Ningdong Granule Upregulates the Striatal DA Transporter and Attenuates Stereotyped Behavior of Tourette Syndrome in Rats[J]. Evidence-based Complementary and Alternative Medicine,2020,2020.

Li, Jijun,Guo, Yi,Zhao, Lin,Sun, Kexing,Xi, Guangjun,&Li, Zai-Wang.(2020).Ningdong Granule Upregulates the Striatal DA Transporter and Attenuates Stereotyped Behavior of Tourette Syndrome in Rats.Evidence-based Complementary and Alternative Medicine,2020.

Li, Jijun,et al."Ningdong Granule Upregulates the Striatal DA Transporter and Attenuates Stereotyped Behavior of Tourette Syndrome in Rats".Evidence-based Complementary and Alternative Medicine 2020(2020).