Chiral nanoparticle-induced amplification in optical activity of molecules with chiral centers

Yang, Lin1,2; Liu, Junjun1,2; Deng, Junhong3; Huang, Zhifeng1,2,4

2020-11

10.1002/inf2.12091

InfoMat   影响因子和分区

2567-3165

2567-3165

Sensitive differentiation of an enantiomer from its mirror image (ie, enantiodifferentiation), a perennial challenge for pharmaceutical production and disease diagnosis, is technically limited by the weak optical activity (OA) of enantiomers, mainly due to their dimensional mismatch with light wavelengths in the ultraviolet (UV)-visible region. Here we use silver chiral nanoparticles (Ag CNPs) with nominally sub-5 nm helical pitch (P) to amplify the OA of (2'R, 3'R, 4'S)-riboflavin-5'-phosphate sodium salts (RP), which have been found to indirectly affect metabolic processes, through the formation of an RP thin film (TF) covering a close-packed array of Ag CNPs. The OA of the RP in the deep-UV region can be amplified up to 80-fold, ascribed to the aggregation of RP in the TFs and the interactions between RP and the atomically chiral lattices at the CNPs' surfaces. The former contribution, not associated with the chiral Ag topographies, plays a dominant role by thickening the RP TFs, so that the observed amplification has no enantioselective dependence on the chirality of the Ag CNPs. This study extends progress in the sensitive detection of bio-enantiomers, which is highly desired for advanced bio-detection in disease diagnosis and production of single-enantiomer pharmaceuticals.

(2'R, 3'R, 4'S)-riboflavin-5'-phosphate sodium salt chiral nanoparticles circular dichroism glancing angle deposition optical activity

ESCI ; SCI

英语

其他

GRF[12200118] ; National Natural Science Foundation of China[91836127] ; SKLP[1920 P06]

Materials Science

Materials Science, Multidisciplinary

WOS:000574524800011

WILEY

Web of Science

1.Hong Kong Baptist Univ HKBU, Dept Phys, Hong Kong, Peoples R China
2.HKBU Inst Res & Continuing Educ, Shenzhen Virtual Univ Pk, Shenzhen, Peoples R China
3.Southern Univ Sci & Technol, Shenzhen Inst Quantum Sci & Engn, Dept Mat Sci & Engn, Shenzhen, Peoples R China
4.Golden Meditech Ctr NeuroRegenerat Sci, Inst Adv Mat, State Key Lab Environm & Biol Anal, Hong Kong, Peoples R China

Yang, Lin,Liu, Junjun,Deng, Junhong,et al. Chiral nanoparticle-induced amplification in optical activity of molecules with chiral centers[J]. InfoMat,2020,2(6):1216-1224.

Yang, Lin,Liu, Junjun,Deng, Junhong,&Huang, Zhifeng.(2020).Chiral nanoparticle-induced amplification in optical activity of molecules with chiral centers.InfoMat,2(6),1216-1224.

Yang, Lin,et al."Chiral nanoparticle-induced amplification in optical activity of molecules with chiral centers".InfoMat 2.6(2020):1216-1224.