Asperochratides A–J, Ten new polyketides from the deep-sea-derived Aspergillus ochraceus

Zou，Zheng Biao1; Zhang，Gang2; Li，Su Mei3; He，Zhi Hui1; Yan，Qing Xiang1; Lin，Yu Kun1; Xie，Chun Lan1; Xia，Jin Mei1; Luo，Zhu Hua1; Luo，Lian Zhong2; Yang，Xian Wen1

2020-12-01

10.1016/j.bioorg.2020.104349

BIOORGANIC CHEMISTRY   影响因子和分区

0045-2068

1090-2120

Ten new C polyketides (asperochratides A–J, 1–10) and 14 known miscellaneous compounds (11–24) were isolated from the deep-sea-derived fungus Aspergillus ochraceus. Structures of the new compounds were elucidated by extensive spectroscopic analyses, modified Mosher's method, Mo(OAc) induced circular dichroism (ICD) experiments, and ECD calculations. Structurally, compounds 1–11 and 16–18 share the same polyketide origin of the skeleton and belong to aspyrone co-metabolites. All isolates were tested for cytotoxic, anti-food allergic, anti-H1N1 virus, anti-microbe, and anti-inflammatory activities in vitro. Results showed that compounds 5–8 and 13–17 exerted significant cytotoxic effects on BV-2 cell line, and compound 16 showed the potential of anti-inflammatory activities.

Aspergillus ochraceus Deep-sea Fungus Polyketides

SCI ; IC

英语

其他

National Natural Science Foundation of China[41676130,21877022] ; Xiamen Southern Oceanographic Center[17GYY002NF02] ; COMRA program[DY135-B2-08]

Biochemistry & Molecular Biology ; Chemistry

Biochemistry & Molecular Biology ; Chemistry, Organic

WOS:000603573700003

ACADEMIC PRESS INC ELSEVIER SCIENCE

BIOLOGY & BIOCHEMISTRY

2-s2.0-85092527691

Scopus

1.Key Laboratory of Marine Biogenetic Resources,Third Institute of Oceanography,Ministry of Natural Resources,Xiamen,184 Daxue Road,361005,China
2.Fujian Province Universities and Colleges Engineering Research Center for Marine Biomedical Resource Utilization,Xiamen Medical College,Xiamen,1999 Guankouzhong Road,361023,China
3.Department of Pharmacology,Shenzhen People's Hospital (The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,518020,China

Zou，Zheng Biao,Zhang，Gang,Li，Su Mei,等. Asperochratides A–J, Ten new polyketides from the deep-sea-derived Aspergillus ochraceus[J]. BIOORGANIC CHEMISTRY,2020,105.

Zou，Zheng Biao.,Zhang，Gang.,Li，Su Mei.,He，Zhi Hui.,Yan，Qing Xiang.,...&Yang，Xian Wen.(2020).Asperochratides A–J, Ten new polyketides from the deep-sea-derived Aspergillus ochraceus.BIOORGANIC CHEMISTRY,105.

Zou，Zheng Biao,et al."Asperochratides A–J, Ten new polyketides from the deep-sea-derived Aspergillus ochraceus".BIOORGANIC CHEMISTRY 105(2020).