Immunogenic exosome-encapsulated black phosphorus nanoparticles as an effective anticancer photo-nanovaccine

Liu，Quan1,2,3; Fan，Taojian4; Zheng，Yuanyuan5; Yang，Sheng Li6; Yu，Zhiqiang7; Duo，Yanhong4; Zhang，Yuhua1,7; Adah，Dickson8; Shi，Lulin1; Sun，Zhe1,2,3; Wang，Dou1; Xie，Jianlei4; Wu，Hong1,7; Wu，Zongze1; Ge，Chenchen1,2,3; Qiao，Lijun1,3; Wei，Chaoying1; Huang，Luodan1,7; Yan，Qiaoting1; Yang，Qinhe2; Bao，Shiyun1; Liu，Li Ping1,9; Zhang，Han4

2020-10-14

10.1039/d0nr05953f

Nanoscale   影响因子和分区

2040-3364

2040-3372

Tumor vaccines are a promising form of cancer immunotherapy, but difficulties such as neo-antigen identification, activation of immune cells, and tumor infiltration prevent their clinical breakthrough. Interestingly, nanotechnology-based photothermal therapy (PTT) has great potential to overcome these barriers. Previous studies have shown that serum exosomes (hEX) from hyperthermia-treated tumor-bearing mice displayed an array of patient-specific tumor-associated antigens (TAAs), and strong immunoregulatory abilities in promoting dendritic cell (DC) differentiation and maturation. Here, we developed a tumor vaccine (hEX@BP) by encapsulating black phosphorus quantum dots (BPQDs) with exosomes (hEX) against a murine subcutaneous lung cancer model. In comparison with BPQDs alone (BP), hEX@BP demonstrated better long-term PTT performance, greater elevation of tumor temperature and tumor targeting efficacy in vivo. Vaccination with hEX@BP in combination with PTT further demonstrated an outstanding therapeutic efficacy against established lung cancer, and promoted the infiltration of T lymphocytes into the tumor tissue. Our findings demonstrated that hEX@BP might be an innovative cancer photo-nanovaccine that offers effective immuno-PTT against cancers.

SCI ; EI

英语

第一 ; 通讯

National Natural Science Foundation of China[61575089][61435010][81903013] ; Science and Technology Innovation Commission of Shenzhen[KQJSCX20180321164801762][KQTD2015032416270385][JCYJ20150625103619275][JCYJ20180507181817604] ; China Postdoctoral Science Foundation[2018M643364][2019M663377][2019M663372] ; PhD Start-up Fund of the Natural Science Foundation of Guangdong Province, China[2018A030310040]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied

WOS:000578100000038

ROYAL SOC CHEMISTRY

2-s2.0-85092726506

Scopus

1.Department of Hepatobiliary and Pancrease Surgery,Shenzhen People's Hospital,Second Clinical Medical College,Jinan University,First Affiliated Hospital,Southern University of Science and Technology,Shenzhen, Guangdong,518020,China
2.School of Traditional Chinese Medicine,Jinan University,Guangzhou, Guangdong,510632,China
3.Integrated Chinese and Western Medicine Postdoctoral Research Station,Jinan University,Guangzhou, Guangdong,510632,China
4.Shenzhen Second People's Hospital,First Affiliated Hospital of Shenzhen University,Collaborative Innovation Center for Optoelectronic Science and Technology of Shenzhen University,Shenzhen,518060,China
5.Translational Medicine Collaborative Innovation Center,Second Clinical Medical College (Shenzhen People's Hospital),Jinan University,Shenzhen,518020,China
6.Cancer Center,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China
7.Guangdong Provincial Key Laboratory of New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou,510515,China
8.State Key Laboratory of Respiratory Disease,Department of Infection and Immunity,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou, Guangdong,510530,China
9.Shenzhen Public Service Platform on Tumor Precision Medicine and Molecular Diagnosis,Shenzhen, Guangdong,518020,China

Liu，Quan,Fan，Taojian,Zheng，Yuanyuan,et al. Immunogenic exosome-encapsulated black phosphorus nanoparticles as an effective anticancer photo-nanovaccine[J]. Nanoscale,2020,12(38):19939-19952.

Liu，Quan.,Fan，Taojian.,Zheng，Yuanyuan.,Yang，Sheng Li.,Yu，Zhiqiang.,...&Zhang，Han.(2020).Immunogenic exosome-encapsulated black phosphorus nanoparticles as an effective anticancer photo-nanovaccine.Nanoscale,12(38),19939-19952.

Liu，Quan,et al."Immunogenic exosome-encapsulated black phosphorus nanoparticles as an effective anticancer photo-nanovaccine".Nanoscale 12.38(2020):19939-19952.