Electronic Blood Vessel

Cheng，Shiyu1,2; Hang，Chen1,2; Ding，Li1,2,3; Jia，Liujun3; Tang，Lixue2; Mou，Lei1,2; Qi，Jie1,2; Dong，Ruihua1,2; Zheng，Wenfu2; Zhang，Yan3; Jiang，Xingyu1,2

2020-11-04

10.1016/j.matt.2020.08.029

Matter   影响因子和分区

2590-2393

2590-2385

Advances in bioelectronics have great potential to address unsolved biomedical problems in the cardiovascular system. By using poly(L-lactide-co-ϵ-caprolactone), which encapsulates liquid metal to make flexible and biodegradable electrical circuitry, we develop an electronic blood vessel that can integrate flexible electronics with three layers of blood-vessel cells, to mimic and go beyond the natural blood vessel. It can improve the endothelialization process through electrical stimulation and can enable controlled gene delivery into specific parts of the blood vessel via electroporation. The electronic blood vessel has excellent biocompatibility in the vascular system and shows great patency 3 months post-implantation in a rabbit model. The electronic blood vessel would be an ideal platform to enable diagnostics and treatments in the cardiovascular system and can greatly empower personalized medicine by creating a direct link of the vascular tissue-machine interface.

bioelectronics blood vessel electrical stimulation electroporation MAP4: Demonstrate metal polymer conductor vascular interface

SCI ; EI

英语

第一 ; 通讯

National Key R&D Program of China[2018YFA0902600][2017YFA0205901] ; National Natural Science Foundation of China[21535001][81730051][21761142006][51973045] ; Chinese Academy of Sciences[QYZDJ-SSW-SLH039][121D11KYSB20170026][XDA16020902] ; Beijing Science and Technology Plan Project[Z191100007619053] ; Postgraduate Innovation Foundation of Peking Union Medical College[2019-1002-28] ; Teaching Reform Foundation of Postgraduate Education in Peking Union Medical College[10023201900202] ; Shenzhen Bay Laboratory[SZBL2019062801004]

Materials Science

Materials Science, Multidisciplinary

WOS:000588450600023

ELSEVIER

20204209369004

Blood ; Biomechanics ; Biocompatibility

Biological Materials and Tissue Engineering:461.2 ; Biomechanics, Bionics and Biomimetics:461.3 ; Immunology:461.9.1

2-s2.0-85092670256

Scopus

1.Department of Biomedical Engineering and Shenzhen Bay Laboratory,Southern University of Science and Technology,Shenzhen,518055,China
2.National Center for NanoScience and Technology,University of Chinese Academy of Sciences,Beijing,100190,China
3.State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100037,China

Cheng，Shiyu,Hang，Chen,Ding，Li,et al. Electronic Blood Vessel[J]. Matter,2020,3(5):1664-1684.

Cheng，Shiyu.,Hang，Chen.,Ding，Li.,Jia，Liujun.,Tang，Lixue.,...&Jiang，Xingyu.(2020).Electronic Blood Vessel.Matter,3(5),1664-1684.

Cheng，Shiyu,et al."Electronic Blood Vessel".Matter 3.5(2020):1664-1684.