题名 | The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET |
作者 | Liu,Chuang1,4 ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
通讯作者 | Zhang,Zheng; Liu,Lei; Wang,Peiyi; Zhang,Peijun |
共同第一作者 | Mendonça,Luiza; Yang,Yang; Gao,Yuanzhu; Shen,Chenguang; Liu,Jiwei |
发表日期 | 2020-11-03
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DOI | |
发表期刊 | |
ISSN | 0969-2126
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EISSN | 1878-4186
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卷号 | 28期号:11页码:1218-1224 |
摘要 | Several vaccine candidates using inactivated SARS-CoV-2 viruses are under development. Liu et al. used state-of-the-art cryoelectron microscopy technologies to characterize the architecture of inactivated SARS-CoV-2 viruses. They found that the viral spikes are mostly in a postfusion state, which is not desirable for vaccine development. |
关键词 | |
相关链接 | [Scopus记录] |
收录类别 | |
语种 | 英语
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学校署名 | 第一
; 共同第一
; 通讯
|
资助项目 | Science and Technology Innovation Committee of Shenzhen Municipality[202002073000002][JSGG 20200207155251653]
; National Institutes of Health[P50A1150481]
; UK Wellcome Trust Investigator Award[206422/Z/17/Z]
; UK Biotechnology and Biological Sciences Research Council[BB/S003339/1]
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WOS研究方向 | Biochemistry & Molecular Biology
; Biophysics
; Cell Biology
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WOS类目 | Biochemistry & Molecular Biology
; Biophysics
; Cell Biology
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WOS记录号 | WOS:000587327300006
|
出版者 | |
ESI学科分类 | BIOLOGY & BIOCHEMISTRY
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Scopus记录号 | 2-s2.0-85092693017
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来源库 | Scopus
|
引用统计 |
被引频次[WOS]:122
|
成果类型 | 期刊论文 |
条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/209113 |
专题 | 生命科学学院_生物系 生命科学学院 南方科技大学医学院 冷冻电镜中心 南方科技大学第二附属医院 |
作者单位 | 1.Department of Biology,Southern University of Science and Technology,Shenzhen,518055,China 2.Division of Structural Biology,Wellcome Trust Centre for Human Genetics,University of Oxford,Oxford,OX3 7BN,United Kingdom 3.Institute for Hepatology,National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital,Shenzhen,518112,China 4.Cryo-EM Center,Southern University of Science and Technology,Shenzhen,518055,China 5.Department for Infectious Diseases,Shenzhen Third People's Hospital,Shenzhen,518112,China 6.The Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China 7.Electron Bio-Imaging Centre,Diamond Light Source,Harwell Science and Innovation Campus,Didcot,OX11 0DE,United Kingdom |
第一作者单位 | 生物系; 生命科学学院; 南方科技大学 |
通讯作者单位 | 南方科技大学医学院; 南方科技大学第二附属医院; 生物系; 生命科学学院; 南方科技大学 |
第一作者的第一单位 | 生物系; 生命科学学院 |
推荐引用方式 GB/T 7714 |
Liu,Chuang,Mendonça,Luiza,Yang,Yang,et al. The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET[J]. STRUCTURE,2020,28(11):1218-1224.
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APA |
Liu,Chuang.,Mendonça,Luiza.,Yang,Yang.,Gao,Yuanzhu.,Shen,Chenguang.,...&Zhang,Peijun.(2020).The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET.STRUCTURE,28(11),1218-1224.
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MLA |
Liu,Chuang,et al."The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET".STRUCTURE 28.11(2020):1218-1224.
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条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | 操作 | |
The Architecture of (2205KB) | -- | -- | 限制开放 | -- |
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