SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in Arabidopsis

Zhang，Yi1; Wang，Hou Ling1; Gao，Yuhan2; Guo，Hongwei1,3; Li，Zhonghai1

2020-10-30

10.3390/ijms21218120

International journal of molecular sciences   影响因子和分区

1661-6596

1422-0067

Leaf senescence is the final stage of leaf development. It is accompanied by the remobilization of nutrients from senescent leaves to developing organs. The occurrence of senescence is the consequence of integrating intrinsic and environmental signals. DNA damage triggered by stresses has been regarded as one of the reasons for senescence. To prevent DNA damage, cells have evolved elaborate DNA repair machinery. The ataxia telangiectasia mutated (ATM) functions as the chief transducer of the double-strand breaks (DSBs) signal. Our previous study suggests that ATM functions in lifespan regulation in Arabidopsis. However, ATM regulatory mechanism on plant longevity remains unclear. Here, we performed chemical mutagenesis to identify the components involved in ATM-mediated longevity and obtained three dominant mutants satmf1~3, suppressor of atm in fertility, displaying delayed senescence and restored fertility in comparison with atm mutant. Molecular cloning and functional analysis of SATMF (suppressor of atm in fertility) will help to understand the underlying regulatory mechanism of ATM in plants, and shed light on developing new treatments for the disease Ataxia-telangiectasia.

ATM DNA damage fertility leaf senescence SATMF

SCI

英语

通讯

National Natural Science Foundation of China[31970196][31570286][31900173] ; Chinese Postdoctoral Science Foundation[2019M650514][2019M650516][2020M670544] ; Shenzhen Science and Technology Program[KQTD20190929173906742] ; National Key Research and Development Program of China[2019YFA0903904]

Biochemistry & Molecular Biology ; Chemistry

Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary

WOS:000588965800001

MDPI

CHEMISTRY

2-s2.0-85095573092

Scopus

1.Beijing Advanced Innovation Center for Tree Breeding by Molecular Design,Beijing Forestry University,100083,China
2.Key Laboratory of Pest Management in Crops of the Ministry of Agriculture,Institute of Plant Protection,Chinese Academy of Agricultural Sciences,100193,China
3.Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes,Department of Biology,Southern University of Science and Technology (SUSTech),Shenzhen,518055,China

Zhang，Yi,Wang，Hou Ling,Gao，Yuhan,et al. SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in Arabidopsis[J]. International journal of molecular sciences,2020,21(21).

Zhang，Yi,Wang，Hou Ling,Gao，Yuhan,Guo，Hongwei,&Li，Zhonghai.(2020).SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in Arabidopsis.International journal of molecular sciences,21(21).

Zhang，Yi,et al."SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in Arabidopsis".International journal of molecular sciences 21.21(2020).