南方科技大学知识苑(SUSTech KC): Effect of HIF-1αsiRNA-linked AuNRs on radiotherapy of nasopharyngeal carcinoma

题名	Effect of HIF-1αsiRNA-linked AuNRs on radiotherapy of nasopharyngeal carcinoma
作者	Xu，Gang 1; Zhang，Haosheng 1; Li，Zhibin 2; Wu，Shihai 1; Quan，Rencui 1; Mao，Kun 1; Sheng，Yang 1; Li，Xianming 1
发表日期	2020-07-31
DOI	10.14715/cmb/2020.66.5.31
发表期刊	CELLULAR AND MOLECULAR BIOLOGY 影响因子和分区
ISSN	0145-5680
EISSN	1165-158X
卷号	66 期号:5页码:185-190
摘要	The radiation sensitivity of tumor cells is closely related to tumor cell hypoxia. Hypoxia-inducible factor-1α (HIF-1α) is considered a key transcription factor which regulates the sensitivity of hypoxic tumor cells to radiotherapy. On the other hand, some studies have shown that gold nanomaterials improve radiation sensitivity. However, studies on the effect of gold nanomaterials carrying HIF-1αsiRNA on tumor radiotherapy, and the underlying mechanisms are limited. Thus, the present study was aimed at investigating the effect of gold nanocomposites (AuNRs) carrying HIF-1αsiRNA (AuNRs-HIF-1αsiRNA) on the radiation sensitivity of nasopharyngeal carcinoma (NPC) hypoxia cells. The effect of AuNRs-HIF-1αsiRNA on radiation sensitivity of hypoxic NPC cells was determined under X-ray irradiation. The results showed that Au-HIF-1αsiRNA improved the radio-sensitivity of NPC tumor. Thus, this study has demonstrated that gold nanomaterials carrying HIF-1αsiRNA effectively increased the radio-sensitivity of hypoxic tumor, thereby improving the effect of radiotherapy on NPC cells.
关键词	HIF-1α Hypoxias. NPC Radiotherapy Sensitivity siRNA uNRs
相关链接	[Scopus记录]
语种	英语
学校署名	第一
ESI学科分类	MOLECULAR BIOLOGY & GENETICS
Scopus记录号	2-s2.0-85092753127
来源库	Scopus
引用统计	被引频次[WOS]：0
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/209195
专题	南方科技大学第一附属医院
作者单位	1.Department of Radiation Oncology,Shenzhen People's Hospital,Second Clinical Medical College,Jinan University,First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,518020,China 2.Materials and Interfaces Center,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,518055,China
第一作者单位	南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Xu，Gang,Zhang，Haosheng,Li，Zhibin,et al. Effect of HIF-1αsiRNA-linked AuNRs on radiotherapy of nasopharyngeal carcinoma[J]. CELLULAR AND MOLECULAR BIOLOGY,2020,66(5):185-190.
APA	Xu，Gang.,Zhang，Haosheng.,Li，Zhibin.,Wu，Shihai.,Quan，Rencui.,...&Li，Xianming.(2020).Effect of HIF-1αsiRNA-linked AuNRs on radiotherapy of nasopharyngeal carcinoma.CELLULAR AND MOLECULAR BIOLOGY,66(5),185-190.
MLA	Xu，Gang,et al."Effect of HIF-1αsiRNA-linked AuNRs on radiotherapy of nasopharyngeal carcinoma".CELLULAR AND MOLECULAR BIOLOGY 66.5(2020):185-190.