Protective Effect of Corynoline in Sepsis-Induced Acute Lung Injury in Rats via Inhibition of NF-ĸB

Shu，Min1; Tang，Yulu2; Liu，Jianzhen3

2020

10.1177/1934578X20961188

Natural Product Communications   影响因子和分区

1934-578X

1555-9475

The present study was conducted to determine the effect of corynoline (COR) against sepsis-induced acute lung injury (ALI) in Wistar rats. Results of the study suggested that COR causes significant inhibition of lipid peroxidation (malondialdehyde) together with inhibition of oxidative stress (superoxide dismutase, catalase, glutathione peroxidase, and myeloperoxidase). The level of various proinflammatory (tumor necrosis factor-alpha, interleukin-8, and migration inhibitory factor) was also found to be reduced in COR-treated rats after sepsis. The protective effect of COR was further substantiated by the histopathology of lung tissue, where it improves the architecture of alveolar spaces. In western blot analysis, COR causes significant inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells activation in the lung tissue homogenate. Our results demonstrated that COR was able to prevent the progression of ALI in rats via inhibition of inflammation and oxidative stress.

cytokines inflammation lung injury oxidative stress sepsis

SCI

英语

通讯

Pharmacology & Pharmacy ; Food Science & Technology

Chemistry, Medicinal ; Food Science & Technology

WOS:000589966100001

SAGE PUBLICATIONS INC

2-s2.0-85095824246

Scopus

1.Department of Emergency,Huazhong University of Science and Technology Union Shenzhen Hospital,Shenzhen,China
2.Department of Dermatological,Affiliated Zhongshan Hospital of Guangdong Medical University (Zhongshan Chenxinghai Hospital),Zhongshan,China
3.Department of Outpatient,Southern University of Science and Technology Hospital,Shenzhen,China

Shu，Min,Tang，Yulu,Liu，Jianzhen. Protective Effect of Corynoline in Sepsis-Induced Acute Lung Injury in Rats via Inhibition of NF-ĸB[J]. Natural Product Communications,2020,15(11).

Shu，Min,Tang，Yulu,&Liu，Jianzhen.(2020).Protective Effect of Corynoline in Sepsis-Induced Acute Lung Injury in Rats via Inhibition of NF-ĸB.Natural Product Communications,15(11).

Shu，Min,et al."Protective Effect of Corynoline in Sepsis-Induced Acute Lung Injury in Rats via Inhibition of NF-ĸB".Natural Product Communications 15.11(2020).