A Soft, Conductive External Stent Inhibits Intimal Hyperplasia in Vein Grafts by Electroporation and Mechanical Restriction

Ding，Li1,2,3; Hang，Chen2,3; Cheng，Shiyu3; Jia，Liujun1; Mou，Lei2,3; Tang，Lixue2,3; Zhang，Chunliang3; Xie，Yangzhouyun2,3; Zheng，Wenfu3; Zhang，Yan1; Jiang，Xingyu2,3

2020-12-22

10.1021/acsnano.0c04827

ACS Nano   影响因子和分区

1936-0851

1936-086X

Intimal hyperplasia (IH) in vein grafts (VGs) is a major issue in coronary artery bypass grafting (CABG) surgery. Although external stents can attenuate IH of VGs to some extent, none of the existing external stents have shown satisfactory clinical outcomes. Here we develop a flexible, biodegradable, and conductive external metal-polymer conductor stent (MPCS) that can electroporate the vessel wall and produce a protein that prevents IH. We designed the plasmid DNA encoding the tissue inhibitor of metalloproteinases-3 (TIMP-3) and lyophilized it on the inner surface of the MPCS to deliver into the adventitia and the middle layer of VGs for gene therapy. Coupled with its continuous mechanical support to prevent dilation after implanting, the MPCS can inhibit the IH of VGs significantly in the rabbit model. This proof-of-concept demonstration may aid the development of other implantable bioelectronics for electroporation gene therapy.

metal-polymer conductor implantable bioelectronics external vascular stent intimal hyperplasia electroporation

SCI ; EI

英语

NI论文

其他

National Key R&D Program of China["2018YFA0902600","2017YFA0205901"] ; National Natural Science Foundation of China[21535001,81730051,21761142006,51973045] ; Chinese Academy of Sciences["QYZDJ-SSW-SLH039","121D11KYSB20170026","X D A 1 6 0 2 0 9 0 2"] ; Shenzhen Bay Laboratory[SZBL2019062801004] ; Beijing Science and Technology Planning Project[Z191100007619053] ; Peking Union Medical College["2019-1002-28",10023201900202]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000603308800041

AMER CHEMICAL SOC

20204409439598

Gene therapy ; Polymeric implants ; Biodegradable polymers

Genetic Engineering:461.8.1 ; Prosthetics:462.4 ; Polymeric Materials:815.1

Web of Science

1.State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100037,China
2.Department of Biomedical Engineering and Shenzhen Bay Laboratory,Southern University of Science and Technology,Shenzhen, Guangdong,No. 1088 Xueyuan Road, Nanshan District,518055,China
3.National Center for NanoScience and Technology,University of Chinese Academy of Sciences,Beijing,100190,China

Ding，Li,Hang，Chen,Cheng，Shiyu,et al. A Soft, Conductive External Stent Inhibits Intimal Hyperplasia in Vein Grafts by Electroporation and Mechanical Restriction[J]. ACS Nano,2020,14(12):16770-16780.

Ding，Li.,Hang，Chen.,Cheng，Shiyu.,Jia，Liujun.,Mou，Lei.,...&Jiang，Xingyu.(2020).A Soft, Conductive External Stent Inhibits Intimal Hyperplasia in Vein Grafts by Electroporation and Mechanical Restriction.ACS Nano,14(12),16770-16780.

Ding，Li,et al."A Soft, Conductive External Stent Inhibits Intimal Hyperplasia in Vein Grafts by Electroporation and Mechanical Restriction".ACS Nano 14.12(2020):16770-16780.