Composite Film with Antibacterial Gold Nanoparticles and Silk Fibroin for Treating Multidrug-Resistant E. coli-Infected Wounds

Zhu, Guoshuai1; Sun, Zhencheng1; Hui, Ping1; Chen, Wenwen1,3; Jiang, Xingyu2

2021-05-10

10.1021/acsbiomaterials.0c01271

ACS Biomaterials Science & Engineering   影响因子和分区

2373-9878

The progressively increasing degree of multiple antibiotic resistance in Gram-negative bacteria challenges the treatment of severe bacterial infection-induced chronic skin wounds. To address this problem, we developed a straightforward strategy to prepare a composite film consisting of antibacterial nanoparticles (4,6diamino-2-pyrimidinethiol-functionalized gold nanoparticles, DAPT-Au NPs) and a silk fibroin (SF) mixed-matrix membrane (DAPT-Au-SF MMM) as a wound dressing for treating multidrug-resistant (MDR) E. coli- induced infection. The good hydrophilicity of SF allows the highly effective release of DAPT-Au NPs from the composite film to combat pathogens within minutes. The antibacterial activity of the composite film is maintained regardless of antimicrobial susceptibility. DAPT-Au-SF MMMs also promote healing in rat wounds infected by clinically isolated MDR E. coli. Our findings provide a new strategy to extend the use of gold nanomaterials and SF-based wound dressings, especially against drugresistant bacterial infections.

gold nanoparticles Bombyx mori silk fibroin antibacterial wound dressing

SCI ; EI

英语

其他

National Natural Science Foundation of China[81701789] ; Shenzhen Basic Research Project[JCYJ20170818144006925]

Materials Science

Materials Science, Biomaterials

WOS:000651052500009

AMER CHEMICAL SOC

20204409436238

Fiber optic sensors ; Drug delivery ; Escherichia coli ; Gold compounds ; Hydrophilicity ; Metal nanoparticles

Fiber Optics:741.1.2 ; Nanotechnology:761

Web of Science

1.Shenzhen Univ, Sch Biomed Engn, Guangdong Key Lab Biomed Measurements & Ultrasoun, Hlth Sci Ctr, Shenzhen 518060, Peoples R China
2.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China
3.Harvard Univ, John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA

Zhu, Guoshuai,Sun, Zhencheng,Hui, Ping,et al. Composite Film with Antibacterial Gold Nanoparticles and Silk Fibroin for Treating Multidrug-Resistant E. coli-Infected Wounds[J]. ACS Biomaterials Science & Engineering,2021,7(5):1827-1835.

Zhu, Guoshuai,Sun, Zhencheng,Hui, Ping,Chen, Wenwen,&Jiang, Xingyu.(2021).Composite Film with Antibacterial Gold Nanoparticles and Silk Fibroin for Treating Multidrug-Resistant E. coli-Infected Wounds.ACS Biomaterials Science & Engineering,7(5),1827-1835.

Zhu, Guoshuai,et al."Composite Film with Antibacterial Gold Nanoparticles and Silk Fibroin for Treating Multidrug-Resistant E. coli-Infected Wounds".ACS Biomaterials Science & Engineering 7.5(2021):1827-1835.