南方科技大学知识苑(SUSTech KC): Structural and functional diversity calls for a new classification of ABC transporters

题名	Structural and functional diversity calls for a new classification of ABC transporters
作者	Thomas，Christoph 1; Aller，Stephen G.2; Beis，Konstantinos 3,4; Carpenter，Elisabeth P.5; Chang，Geoffrey 6; Chen，Lei 7,8; Dassa，Elie 9; Dean，Michael 10; Duong Van Hoa，Franck 11; Ekiert，Damian 12; Ford，Robert 13; Gaudet，Rachelle 14; Gong，Xin15 ; Holland，I. Barry 16; Huang，Yihua 17; Kahne，Daniel K.18; Kato，Hiroaki 19; Koronakis，Vassilis 20; Koth，Christopher M.21; Lee，Youngsook 22; Lewinson，Oded 23; Lill，Roland 24; Martinoia，Enrico 25,26; Murakami，Satoshi 27; Pinkett，Heather W.28; Poolman，Bert 29; Rosenbaum，Daniel 30; Sarkadi，Balazs 31; Schmitt，Lutz 32; Schneider，Erwin 33; Shi，Yigong 34; Shyng，Show Ling 35; Slotboom，Dirk J.29; Tajkhorshid，Emad 36; Tieleman，D. Peter 37; Ueda，Kazumitsu 38; Váradi，András 31; Wen，Po Chao 36; Yan，Nieng 39; Zhang，Peng 40; Zheng，Hongjin 41; Zimmer，Jochen 42; Tampé，Robert 1
通讯作者	Thomas，Christoph
发表日期	2020
DOI	10.1002/1873-3468.13935
发表期刊	FEBS LETTERS 影响因子和分区
ISSN	0014-5793
EISSN	1873-3468
摘要	Members of the ATP-binding cassette (ABC) transporter superfamily translocate a broad spectrum of chemically diverse substrates. While their eponymous ATP-binding cassette in the nucleotide-binding domains (NBDs) is highly conserved, their transmembrane domains (TMDs) forming the translocation pathway exhibit distinct folds and topologies, suggesting that during evolution the ancient motor domains were combined with different transmembrane mechanical systems to orchestrate a variety of cellular processes. In recent years, it has become increasingly evident that the distinct TMD folds are best suited to categorize the multitude of ABC transporters. We therefore propose a new ABC transporter classification that is based on structural homology in the TMDs.
关键词	Abc Transporters Atpases Cryo-em Membrane Proteins Molecular Machines Phylogeny Primary Active Transporters Sequence Alignment Structural Biology X-ray Crystallography
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
重要成果	ESI高被引
学校署名	其他
WOS记录号	WOS:000583296400001
ESI学科分类	BIOLOGY & BIOCHEMISTRY
Scopus记录号	2-s2.0-85093960508
来源库	Scopus
引用统计	被引频次[WOS]：156
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/209286
专题	生命科学学院_生物系生命科学学院
作者单位	1.Institute of Biochemistry,Biocenter,Goethe University Frankfurt,Germany 2.Department of Pharmacology and Toxicology,University of Alabama at Birmingham,United States 3.Department of Life Sciences,Imperial College London,London South Kensington,United Kingdom 4.Rutherford Appleton Laboratory,Research Complex at Harwell,Didcot,United Kingdom 5.Structural Genomics Consortium,University of Oxford,United Kingdom 6.Skaggs School of Pharmacy and Pharmaceutical Sciences and Department of Pharmacology,School of Medicine,University of California,San Diego,La Jolla,United States 7.State Key Laboratory of Membrane Biology,Institute of Molecular Medicine,Beijing Key Laboratory of Cardiometabolic Molecular Medicine,Peking University,Beijing,China 8.Peking-Tsinghua Center for Life Sciences,Peking University,Beijing,China 9.Institut Pasteur,Paris Cedex 15,France 10.Division of Cancer Epidemiology and Genetics,National Cancer Institute,NIH,Gaithersburg,United States 11.Department of Biochemistry and Molecular Biology,Faculty of Medicine,Life Sciences Institute,University of British Columbia,Vancouver,Canada 12.Department of Cell Biology and Department of Microbiology,New York University School of Medicine,United States 13.Faculty of Biology,Medicine and Health,The University of Manchester,United Kingdom 14.Department of Molecular and Cellular Biology,Harvard University,Cambridge,United States 15.Department of Biology,Southern University of Science and Technology,Shenzhen,China 16.Institute for Integrative Biology of the Cell (I2BC),Université Paris-Sud,Orsay,France 17.National Laboratory of Biomacromolecules,CAS Center for Excellence in Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing,China 18.Department of Chemistry and Chemical Biology,Harvard University,Cambridge,United States 19.Institute for Integrated Cell-Material Sciences (WPI-iCeMS),Kyoto University,Japan 20.Department of Pathology,University of Cambridge,United Kingdom 21.Structural Biology,Genentech Inc.,South San Francisco,United States 22.Division of Integrative Bioscience and Biotechnology,POSTECH,Pohang,South Korea 23.Department of Biochemistry,The Bruce and Ruth Rappaport Faculty of Medicine,The Technion-Israel Institute of Technology,Haifa,Israel 24.Institut für Zytobiologie,Philipps-Universität Marburg,Germany 25.Department of Plant and Microbial Biology,University Zurich,Switzerland 26.International Research Centre for Environmental Membrane Biology,Foshan University,Foshan,China 27.Department of Life Science,Tokyo Institute of Technology,Yokohama,Japan 28.Department of Molecular Biosciences,Northwestern University,Evanston,United States 29.Department of Biochemistry,Groningen Biomolecular Sciences and Biotechnology Institute,University of Groningen,Netherlands 30.Department of Biophysics,University of Texas Southwestern Medical Center,Dallas,United States 31.Institute of Enzymology,Research Center for Natural Sciences (RCNS),Budapest,Hungary 32.Institute of Biochemistry,Heinrich Heine University Düsseldorf,Düsseldorf,Germany 33.Department of Biology/Microbial Physiology,Humboldt-University of Berlin,Germany 34.Institute of Biology,Westlake Institute for Advanced Study,School of Life Sciences,Westlake University,Hangzhou,China 35.Department of Chemical Physiology and Biochemistry,Oregon Health & Science University,Portland,United States 36.Department of Biochemistry,Center for Biophysics and Quantitative Biology,NIH Center for Macromolecular Modeling and Bioinformatics,Beckman Institute for Advanced Science and Technology,University of Illinois at Urbana-Champaign,United States 37.Department of Biological Sciences and Centre for Molecular Simulation,University of Calgary,Canada 38.Institute for Integrated Cell-Material Sciences (WPI-iCeMS),KUIAS,Kyoto University,Japan 39.Department of Molecular Biology,Princeton University,United States 40.National Key Laboratory of Plant Molecular Genetics,CAS Center for Excellence in Molecular Plant Sciences,Institute of Plant Physiology and Ecology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,China 41.Department of Biochemistry and Molecular Genetics,School of Medicine,University of Colorado Anschutz Medical Campus,Aurora,United States 42.Molecular Physiology and Biological Physics,University of Virginia School of Medicine,Charlottesville,United States
推荐引用方式 GB/T 7714	Thomas，Christoph,Aller，Stephen G.,Beis，Konstantinos,et al. Structural and functional diversity calls for a new classification of ABC transporters[J]. FEBS LETTERS,2020.
APA	Thomas，Christoph.,Aller，Stephen G..,Beis，Konstantinos.,Carpenter，Elisabeth P..,Chang，Geoffrey.,...&Tampé，Robert.(2020).Structural and functional diversity calls for a new classification of ABC transporters.FEBS LETTERS.
MLA	Thomas，Christoph,et al."Structural and functional diversity calls for a new classification of ABC transporters".FEBS LETTERS (2020).