Epidemiological Realities of Alcoholic Liver Disease: Global Burden, Research Trends, and Therapeutic Promise

Xiao，Jia1; Wang，Fei2; Wong，Nai Kei3; Lv，Yi1; Liu，Yingxia3; Zhong，Jiajun4; Chen，Shuaiyin5; Li，Wei6; Koike，Kazuo6; Liu，Xiaowei7; Wang，Hua8

2020-11-11

10.3727/105221620X15952664091823

GENE EXPRESSION   影响因子和分区

1052-2166

1555-3884

Globally, alcohol consumption contributes to more than 3 million deaths each year. While much of its ramifications is preventable, a coherent public health discourse on how to limit alcohol-related harm has been overdue. By synthesizing information from national and global databases, we show in this analysis that alcohol consumption level and alcohol-attributable burden of diseases, particularly alcoholic liver disease (ALD), are intimately linked to national income distribution, cultural norms, religion, sex, age, and health status. Prevalence and burden of ALD are positively associated with economic standing in most countries, which necessitate active governmental control via cost-effective policies, such as the best buys proposed by the World Health Organization. To date, a number of critical questions remain unanswered over the molecular mechanisms underlying ALD pathophysiology; the insights gained thereof should provide new opportunities for the advancement of novel diagnostic and management strategies. In comparison with other prevailing liver diseases (e.g., viral hepatitis and nonalcoholic fatty liver disease), governmental support to ALD investigation has been sluggish in most Western countries and China, resulting in a dearth of breakthroughs on both the basic and clinical research fronts in the past decades. Emerging foci of clinical trials for ALD therapy include empirical use of probiotics, antioxidants, growth factors, monoclonal antibodies against key inflammatory mediators, and technology-enhanced behavioral interventions. In this article, we seek to provide a comprehensive analysis on the progress and challenges in tackling ALD as a global health problem, with particular emphasis on global disease burden, socioeconomic influences, research trends, government roles, and future therapies.

英语

其他

MOLECULAR BIOLOGY & GENETICS

2-s2.0-85095974961

Scopus

1.Laboratory of Neuroendocrinology,Fujian Key Laboratory of Developmental and Neuro Biology,School of Life Sciences,Fujian Normal UniversityFuzhouChina,
2.Division of Gastroenterology,Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenChina,
3.National Clinical Research Center for Infectious Diseases,Shenzhen Third Peoples Hospital,Second Hospital Affiliated to Southern University of Science and TechnologyShenzhenChina,
4.Clinical Medicine Research Institute,First Affiliated Hospital of Jinan UniversityGuangzhouChina,
5.Department Epidemiology,College of Public Health,
6.Faculty of Pharmaceutical Sciences,
7.Department of Gastroenterology,Xiangya Hospital,Central South UniversityChangshaChina,
8.Department of Oncology,First Affiliated Hospital,Institute for Liver Diseases of Anhui Medical UniversityHefeiChina,

Xiao，Jia,Wang，Fei,Wong，Nai Kei,et al. Epidemiological Realities of Alcoholic Liver Disease: Global Burden, Research Trends, and Therapeutic Promise[J]. GENE EXPRESSION,2020,20(2):105-118.

Xiao，Jia.,Wang，Fei.,Wong，Nai Kei.,Lv，Yi.,Liu，Yingxia.,...&Wang，Hua.(2020).Epidemiological Realities of Alcoholic Liver Disease: Global Burden, Research Trends, and Therapeutic Promise.GENE EXPRESSION,20(2),105-118.

Xiao，Jia,et al."Epidemiological Realities of Alcoholic Liver Disease: Global Burden, Research Trends, and Therapeutic Promise".GENE EXPRESSION 20.2(2020):105-118.