Longitudinal Changes on Clinical Features in 28 Children With COVID-19 in Shenzhen, China

Liao，Xuejiao1; Liu，Jiaye1; He，Ziyi1; Hu，Ming1; Xiao，Tongyang1; Wei，Lanlan1; Cai，Qiue1; Wang，Haiyan1; He，Qing1; Liu，Lei1; Zhang，Zheng2

2020-11-04

10.3389/fmed.2020.579406

Frontiers in Medicine   影响因子和分区

2296-858X

2296-858X

Objective: To investigate the clinical characteristics of children with coronavirus disease 2019 (COVID-19) and identify the occurrence of viral shedding of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) during follow-up. Methods: We retrospectively retrieved data from pediatric patients with COVID-19 from the Shenzhen Third People's Hospital in China. The dynamics of SARS-CoV-2 and antibodies against SARS-CoV-2 were analyzed during hospitalization and after discharge. Results: From January 23 to March 15, 2020, a total of 28 pediatric patients were diagnosed with COVID-19 and were followed for at least 1 month. The median age was 7 years (IQR 3.5–10) and none of the children progressed to severe COVID-19 during hospitalization. Ten patients tested positive for SARS-CoV-2 1 month after discharge while four patients tested positive during the 2nd month after discharge. Only three of 12 children showed detectable immunoglobulin-M (IgM) on day 5, 18, and 21 after illness onset, respectively. Conclusions: COVID-19 disease was relatively mild among children while a number did test positive after discharge from the hospital. Public health initiatives should thus adapt control measures targeted toward children.

antibody clinical features coronavirus disease 2019 (COVID-19) pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

SCI

英语

第一 ; 通讯

Sanming Project of Medicine in Shenzhen[SZSM201612014]

General & Internal Medicine

Medicine, General & Internal

WOS:000591618900001

FRONTIERS MEDIA SA

2-s2.0-85096196463

Scopus

1.The Third People's Hospital of Shenzhen,The Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,China
2.Institute of Hepatology,Shenzhen Third People's Hospital,Shenzhen,China

Liao，Xuejiao,Liu，Jiaye,He，Ziyi,et al. Longitudinal Changes on Clinical Features in 28 Children With COVID-19 in Shenzhen, China[J]. Frontiers in Medicine,2020,7.

Liao，Xuejiao.,Liu，Jiaye.,He，Ziyi.,Hu，Ming.,Xiao，Tongyang.,...&Zhang，Zheng.(2020).Longitudinal Changes on Clinical Features in 28 Children With COVID-19 in Shenzhen, China.Frontiers in Medicine,7.

Liao，Xuejiao,et al."Longitudinal Changes on Clinical Features in 28 Children With COVID-19 in Shenzhen, China".Frontiers in Medicine 7(2020).