Noncoding RNAs in subchondral bone osteoclast function and their therapeutic potential for osteoarthritis

Duan，Li1; Liang，Yujie2; Xu，Xiao1; Wang，Jifeng1; Li，Xingfu1; Sun，Deshun1; Deng，Zhiqin1; Li，Wencui3; Wang，Daping1,4

2020-12-01

10.1186/s13075-020-02374-x

Arthritis Research and Therapy   影响因子和分区

1478-6354

1478-6362

Osteoclasts are the only cells that perform bone resorption. Noncoding RNAs (ncRNAs) are crucial epigenetic regulators of osteoclast biological behaviors ranging from osteoclast differentiation to bone resorption. The main ncRNAs, including miRNAs, circRNAs, and lncRNAs, compose an intricate network that influences gene transcription processes related to osteoclast biological activity. Accumulating evidence suggests that abnormal osteoclast activity leads to the disturbance of subchondral bone remodeling, thus initiating osteoarthritis (OA), a prevalent joint disease characterized mainly by cartilage degradation and subchondral bone remodeling imbalance. In this review, we delineate three types of ncRNAs and discuss their related complex molecular signaling pathways associated with osteoclast function during bone resorption. We specifically focused on the involvement of noncoding RNAs in subchondral bone remodeling, which participate in the degradation of the osteochondral unit during OA progression. We also discussed exosomes as ncRNA carriers during the bone remodeling process. A better understanding of the roles of ncRNAs in osteoclast biological behaviors will contribute to the treatment of bone resorption-related skeletal diseases such as OA.

Noncoding RNAs Osteoarthritis Osteoclasts Subchondral bone remodeling

SCI

英语

其他

National Natural Science Foundation of China[81772394][81972116] ; Key Program of Natural Science Foundation of Guangdong Province[2018B0303110003] ; Shenzhen Science and Technology Projects[KQTD20170331100838136]

Rheumatology

Rheumatology

WOS:000595804200002

BMC

CLINICAL MEDICINE

2-s2.0-85096551973

Scopus

1.Department of Orthopaedics,Shenzhen Intelligent Orthopaedics and Biomedical Innovation Platform,Guangdong Artificial Intelligence Biomedical Innovation Platform,Shenzhen Second People’s Hospital,The First Affiliated Hospital of Shenzhen University Health Science Center,Shenzhen,518035,China
2.Department of Child and Adolescent Psychiatry,Shenzhen Kangning Hospital,Shenzhen Mental Health Center,Shenzhen Key Laboratory for Psychological Healthcare & Shenzhen Institute of Mental Health,Shenzhen,518003,China
3.Hand and Foot Surgery Department,Shenzhen Second People’s Hospital,Shenzhen,518035,China
4.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China

Duan，Li,Liang，Yujie,Xu，Xiao,et al. Noncoding RNAs in subchondral bone osteoclast function and their therapeutic potential for osteoarthritis[J]. Arthritis Research and Therapy,2020,22(1).

Duan，Li.,Liang，Yujie.,Xu，Xiao.,Wang，Jifeng.,Li，Xingfu.,...&Wang，Daping.(2020).Noncoding RNAs in subchondral bone osteoclast function and their therapeutic potential for osteoarthritis.Arthritis Research and Therapy,22(1).

Duan，Li,et al."Noncoding RNAs in subchondral bone osteoclast function and their therapeutic potential for osteoarthritis".Arthritis Research and Therapy 22.1(2020).