Polymethine-Based Semiconducting Polymer Dots with Narrow-Band Emission and Absorption/Emission Maxima at NIR-II for Bioimaging

Liu，Ming Ho1; Zhang，Zhe2; Yang，Yu Chi1; Chan，Yang Hsiang1,3

2020

10.1002/anie.202011914

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   影响因子和分区

1433-7851

1521-3773

Deep-penetration fluorescence imaging in the second near-infrared (NIR-II) window heralds a new era of clinical surgery, in which high-resolution vascular/lymphatic anatomy and detailed cancerous tissues can be visualized in real time. Described here is a series of polymethine-based semiconducting polymers with intrinsic emission maxima in the NIR-IIa (1300–1400 nm) window and absorption maxima ranging from 1082 to 1290 nm. These polymers were prepared as semiconducting polymer dots (Pdots) in aqueous solutions with fluorescence quantum yields of 0.05–0.18 %, and they demonstrate promising applications in noninvasive through-skull brain imaging in live mice with remarkable spatial resolution as well as signal-to-background contrast. This study offers a platform for future design of NIR-IIa or even NIR-IIb emitting Pdots.

dyes/pigments fluorescence imaging agents polymers synthetic methods

SCI ; EI ; IC

英语

NI论文

其他

MOST, Taiwan[1052113-M-110-012-MY3]

Chemistry

Chemistry, Multidisciplinary

WOS:000587743700001

WILEY-V C H VERLAG GMBH

20204809555357

Brain mapping ; Semiconducting polymers ; Fluorescence imaging ; Infrared devices

Biomedical Engineering:461.1 ; Semiconducting Materials:712.1 ; Imaging Techniques:746

CHEMISTRY

2-s2.0-85096713059

Scopus

1.Department of Applied Chemistry/Center for Emergent Functional Matter Science,National Chiao Tung University,Hsinchu,30050,Taiwan
2.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
3.Department of Medicinal and Applied Chemistry,Kaohsiung Medical University,Kaohsiung,80708,Taiwan

Liu，Ming Ho,Zhang，Zhe,Yang，Yu Chi,et al. Polymethine-Based Semiconducting Polymer Dots with Narrow-Band Emission and Absorption/Emission Maxima at NIR-II for Bioimaging[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020,60(2):983-989.

Liu，Ming Ho,Zhang，Zhe,Yang，Yu Chi,&Chan，Yang Hsiang.(2020).Polymethine-Based Semiconducting Polymer Dots with Narrow-Band Emission and Absorption/Emission Maxima at NIR-II for Bioimaging.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,60(2),983-989.

Liu，Ming Ho,et al."Polymethine-Based Semiconducting Polymer Dots with Narrow-Band Emission and Absorption/Emission Maxima at NIR-II for Bioimaging".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 60.2(2020):983-989.