Bright Aggregation-Induced Emission Nanoparticles for Two-Photon Imaging and Localized Compound Therapy of Cancers

Li，Ying1; Tang，Rongbing3,5; Liu，Xiaoyan2,5; Gong，Junyi4; Zhao，Zujin7; Sheng，Zonghai6; Zhang，Jiangjiang2; Li，Xuanyu2; Niu，Guangle4; Kwok，Ryan T.K.4; Zheng，Wenfu5; Jiang，Xingyu2; Tang，Ben Zhong1,4,7

2020-12-22

10.1021/acsnano.0c05610

ACS Nano   影响因子和分区

1936-0851

1936-086X

Photodynamic therapy (PDT), a noninvasive therapeutic strategy for cancer treatment, which always suffers from the low reactive oxygen species (ROS) yield of traditional organic dyes. Herein, we present lipid-encapsulated aggregation-induced emission nanoparticles (ME NPs) that have a high quantum yield (23%) and a maximum two-photon absorption (TPA) cross-section of 560 GM irradiated by near-infrared light (800 nm). The AIE NPs can serve as imaging agents for spatiotemporal imaging of tumor tissues with a penetration depth up to 505 mu m on mice melanoma model. Importantly, the AIE NPs can simultaneously generate singlet oxygen (O-1(2)) and highly toxic hydroxyl radicals (center dot OH) upon irradiation with 800 nm irradiation for photodynamic tumor ablation. In addition, the ME NPs can be effectively cleared from the mouse body after the imaging and therapy. This study provides a strategy to develop theranostic agents for cancer image-guided PDT with high brightness, superior photostability, and high biosafety.

aggregation-induced emission photodynamic therapy two-photon fluorescence imaging

SCI ; EI

英语

NI期刊

其他

Research Grants Council of Hong Kong[C6009-17G] ; Innovation and Technology Commission[ITC-CNERC14SC01] ; National Key Research and Development Program of China["2018YFE0190200","2018YFA0902600"] ; Natural Science Foundation of China[21761142006,81673039] ; Chinese Academy of Sciences["QYZDJ-SSW-SLH039","121D11KYSB20170026","XDA16020902"] ; Fundamental Research Funds for the Central Universities[lzujbky-2020-51]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000603308800048

AMER CHEMICAL SOC

20204809542596

Oxygen ; Photons ; Fluorescence imaging ; Two photon processes ; Mammals ; Infrared devices ; Nanoparticles ; Tumors ; Diseases ; Luminescence of organic solids ; Noninvasive medical procedures ; Irradiation

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Light/Optics:741.1 ; Imaging Techniques:746 ; Nanotechnology:761 ; Chemical Products Generally:804 ; Organic Compounds:804.1 ; Physical Properties of Gases, Liquids and Solids:931.2 ; Atomic and Molecular Physics:931.3 ; Solid State Physics:933

Web of Science

1.Center for Aie Research,College of Materials Science and Engineering,Shenzhen University,Shenzhen,518061,China
2.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen, Nanshan District,No. 1088 Xueyuan Rd,518055,China
3.School of Stomatology,Lanzhou University,Lanzhou,199 Donggang Western Rd,730000,China
4.Department of Chemistry,Hong Kong Br. of Chinese Natl. Engineering Research Center for Tissue Restoration and Reconstruction,Hong Kong University of Science and Technology,Clear Water Bay,Kowloon, Hong Kong,China
5.Gba Research Innovation Institute for Nanotechnology,Cas Key Lab for Biological Effects of Nanomaterials and Nanosafety,National Center for NanoScience and Technology,BeiYiTiao,Beijing, Zhongguancun,100190,China
6.Paul C. Lauterbur Research Center for Biomedical Imaging,Shenzhen Key Laboratory of Ultrasound Imaging and Therapy,Cas Key Laboratory of Health Informatics,Institute of Biomedical and Health Engineering,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,518055,China
7.State Key Laboratory of Luminescent Materials and Devices,Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates,South China University of Technology,Guangzhou,510640,China

Li，Ying,Tang，Rongbing,Liu，Xiaoyan,et al. Bright Aggregation-Induced Emission Nanoparticles for Two-Photon Imaging and Localized Compound Therapy of Cancers[J]. ACS Nano,2020,14(12):16840-16853.

Li，Ying.,Tang，Rongbing.,Liu，Xiaoyan.,Gong，Junyi.,Zhao，Zujin.,...&Tang，Ben Zhong.(2020).Bright Aggregation-Induced Emission Nanoparticles for Two-Photon Imaging and Localized Compound Therapy of Cancers.ACS Nano,14(12),16840-16853.

Li，Ying,et al."Bright Aggregation-Induced Emission Nanoparticles for Two-Photon Imaging and Localized Compound Therapy of Cancers".ACS Nano 14.12(2020):16840-16853.