Polyetheretherketone and Its Composites for Bone Replacement and Regeneration

Liao, Chengzhu1; Li, Yuchao2; Tjong, Sie Chin3

2020-12-01

10.3390/polym12122858

POLYMERS   影响因子和分区

2073-4360

In this article, recent advances in the development, preparation, biocompatibility and mechanical properties of polyetheretherketone (PEEK) and its composites for hard and soft tissue engineering are reviewed. PEEK has been widely employed for fabricating spinal fusions due to its radiolucency, chemical stability and superior sterilization resistance at high temperatures. PEEK can also be tailored into patient-specific implants for treating orbital and craniofacial defects in combination with additive manufacturing process. However, PEEK is bioinert, lacking osseointegration after implantation. Accordingly, several approaches including surface roughening, thin film coating technology, and addition of bioactive hydroxyapatite (HA) micro-/nanofillers have been adopted to improve osseointegration performance. The elastic modulus of PEEK is 3.7-4.0 GPa, being considerably lower than that of human cortical bone ranging from 7-30 GPa. Thus, PEEK is not stiff enough to sustain applied stress in load-bearing orthopedic implants. Therefore, HA micro-/nanofillers, continuous and discontinuous carbon fibers are incorporated into PEEK for enhancing its stiffness for load-bearing applications. Among these, carbon fibers are more effective than HA micro-/nanofillers in providing additional stiffness and load-bearing capabilities. In particular, the tensile properties of PEEK composite with 30wt% short carbon fibers resemble those of cortical bone. Hydrophobic PEEK shows no degradation behavior, thus hampering its use for making porous bone scaffolds. PEEK can be blended with hydrophilic polymers such as polyglycolic acid and polyvinyl alcohol to produce biodegradable scaffolds for bone tissue engineering applications.

polyetheretherketone hydroxyapatite composite implant osteoblast bone biocompatibility elastic modulus carbon fiber scaffold

SCI ; EI

英语

第一

Polymer Science

Polymer Science

WOS:000602521400001

MDPI

20204909578751

Biocompatibility ; Scaffolds (biology) ; Biodegradable polymers ; Carbon fibers ; Polymeric implants ; Biomechanics ; Bone ; Elastic moduli ; Chemical stability ; Stiffness ; Bearings (machine parts) ; Biodegradation

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Biomechanics, Bionics and Biomimetics:461.3 ; Biotechnology:461.8 ; Immunology:461.9.1 ; Prosthetics:462.4 ; Machine Components:601.2 ; Chemistry:801 ; Biochemistry:801.2 ; Chemical Products Generally:804 ; Inorganic Compounds:804.2 ; Polymeric Materials:815.1 ; Materials Science:951

Web of Science

1.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China
2.Liaocheng Univ, Dept Mat Sci & Engn, Liaocheng 252000, Shandong, Peoples R China
3.City Univ Hong Kong, Dept Phys, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China

Liao, Chengzhu,Li, Yuchao,Tjong, Sie Chin. Polyetheretherketone and Its Composites for Bone Replacement and Regeneration[J]. POLYMERS,2020,12(12):1-48.

Liao, Chengzhu,Li, Yuchao,&Tjong, Sie Chin.(2020).Polyetheretherketone and Its Composites for Bone Replacement and Regeneration.POLYMERS,12(12),1-48.

Liao, Chengzhu,et al."Polyetheretherketone and Its Composites for Bone Replacement and Regeneration".POLYMERS 12.12(2020):1-48.