Recent advances in zinc oxide nanostructures with antimicrobial activities

Li，Yuchao1; Liao，Chengzhu2; Tjong，Sie Chin3

2020-11-02

10.3390/ijms21228836

International Journal of Molecular Sciences   影响因子和分区

1661-6596

1422-0067

This article reviews the recent developments in the synthesis, antibacterial activity, and visible-light photocatalytic bacterial inactivation of nano-zinc oxide. Polycrystalline wurtzite ZnO nanostructures with a hexagonal lattice having different shapes can be synthesized by means of vapor-, liquid-, and solid-phase processing techniques. Among these, ZnO hierarchical nanostructures prepared from the liquid phase route are commonly used for antimicrobial activity. In particular, plant extract-mediated biosynthesis is a single step process for preparing nano-ZnO without using surfactants and toxic chemicals. The phytochemical molecules of natural plant extracts are attractive agents for reducing and stabilizing zinc ions of zinc salt precursors to form green ZnO nanostructures. The peel extracts of certain citrus fruits like grapefruits, lemons and oranges, acting as excellent chelating agents for zinc ions. Furthermore, phytochemicals of the plant extracts capped on ZnO nanomaterials are very effective for killing various bacterial strains, leading to low minimum inhibitory concentration (MIC) values. Bioactive phytocompounds from green ZnO also inhibit hemolysis of Staphylococcus aureus infected red blood cells and inflammatory activity of mammalian immune system. In general, three mechanisms have been adopted to explain bactericidal activity of ZnO nanomaterials, including direct contact killing, reactive oxygen species (ROS) production, and released zinc ion inactivation. These toxic effects lead to the destruction of bacterial membrane, denaturation of enzyme, inhibition of cellular respiration and deoxyribonucleic acid replication, causing leakage of the cytoplasmic content and eventual cell death. Meanwhile, antimicrobial activity of doped and modified ZnO nanomaterials under visible light can be attributed to photogeneration of ROS on their surfaces. Thus particular attention is paid to the design and synthesis of visible light-activated ZnO photocatalysts with antibacterial properties.

Antimicrobial activity Contact killing Free radicals Hemolysis Heterostructure Photocatalytic activity Phytocompounds Semiconducting oxide Synthesis Zinc ion

SCI

英语

通讯

Natural Science Foundation of Shandong Province, China[ZR2019MB053] ; National Youth Science Foundation, China[21703096]

Biochemistry & Molecular Biology ; Chemistry

Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary

WOS:000594882600001

MDPI

CHEMISTRY

2-s2.0-85096894919

Scopus

1.Department of Materials Science and Engineering,Liaocheng University,Liaocheng,252000,China
2.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China
3.Department of Physics,City University of Hong Kong,Kowloon,Tat Chee Avenue,Hong Kong

Li，Yuchao,Liao，Chengzhu,Tjong，Sie Chin. Recent advances in zinc oxide nanostructures with antimicrobial activities[J]. International Journal of Molecular Sciences,2020,21(22):1-70.

Li，Yuchao,Liao，Chengzhu,&Tjong，Sie Chin.(2020).Recent advances in zinc oxide nanostructures with antimicrobial activities.International Journal of Molecular Sciences,21(22),1-70.

Li，Yuchao,et al."Recent advances in zinc oxide nanostructures with antimicrobial activities".International Journal of Molecular Sciences 21.22(2020):1-70.